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Toxicity assessment : = methods and ...

Palmeira, Carlos M.

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Toxicity assessment : = methods and protocols /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Toxicity assessment :/ edited by Carlos Manuel Marques Palmeira, Danielle Palma de Oliveira, Daniel Junqueira Dorta.
其他題名:	methods and protocols /
其他作者:	Palmeira, Carlos M.
出版者:	New York, NY :Humana Press, : 2021.,
面頁冊數:	xii, 266 p. :ill. (some col.) ;26 cm.
內容註:	The Single Cell Gel Electrophoresis Genotoxin Sensitivity Assay -- Skin Sensitization Tests: The LLNA and the RhE IL-18 Potency Assay -- Skin Equivalent Models: Protocols for In Vitro Reconstruction for Dermal Toxicity Evaluation -- Intravital Microscopy: A Tool to Investigate the Toxicity in the Immune System, Vessel Rheology, and Xenobiotic Distribution -- Cell-Based Biosensor to Visualize Nitric Oxide Release from Living Cells for Toxicity Assessment -- In Vitro Contraction of Isolated Cauda Epididymal Duct Smooth Muscle as a Complimentary Approach to Physiological, Pathological, Toxicological, and Pharmacological Studies on Epididymal Function -- Early Life Stage Assays in Zebrafish -- Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ -- Evaluation of Development of the Rat Uterus as a Toxicity Biomarker -- Acetylcholinesterase (AChE) Activity in Embryos of Zebrafish -- Ecotoxicity Assays Using Freshwater Planarians -- Toxicogenomic Analysis -- Strategy Combining Non-Animal Methods for Ocular Toxicity Evaluation -- Immunocytochemistry Analysis of HepG2 Cell 3D Culture Encapsulated as Spheroids in Alginate Beads -- Oxygen Consumption Evaluation: An Important Indicator of Metabolic State, Cellular Function and Cell Fate Along Neural Deregulation -- Mitochondrial Bioenergetic Assays as a Standard Protocol for Toxicological and Metabolic Assessment -- In Vitro Apoptotic Cell Death Assessment.
標題:	Toxicology - Laboratory manuals. -
ISBN:	9781071610930

Toxicity assessment : = methods and protocols /
Toxicity assessment :methods and protocols /edited by Carlos Manuel Marques Palmeira, Danielle Palma de Oliveira, Daniel Junqueira Dorta. - New York, NY :Humana Press,2021. - xii, 266 p. :ill. (some col.) ;26 cm. - Methods in molecular biology,volume 22401940-6029 ;. - Methods in molecular biology (Clifton, N.J.) ;v. 2240..

Includes bibliographical references and index.

The Single Cell Gel Electrophoresis Genotoxin Sensitivity Assay -- Skin Sensitization Tests: The LLNA and the RhE IL-18 Potency Assay -- Skin Equivalent Models: Protocols for In Vitro Reconstruction for Dermal Toxicity Evaluation -- Intravital Microscopy: A Tool to Investigate the Toxicity in the Immune System, Vessel Rheology, and Xenobiotic Distribution -- Cell-Based Biosensor to Visualize Nitric Oxide Release from Living Cells for Toxicity Assessment -- In Vitro Contraction of Isolated Cauda Epididymal Duct Smooth Muscle as a Complimentary Approach to Physiological, Pathological, Toxicological, and Pharmacological Studies on Epididymal Function -- Early Life Stage Assays in Zebrafish -- Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ -- Evaluation of Development of the Rat Uterus as a Toxicity Biomarker -- Acetylcholinesterase (AChE) Activity in Embryos of Zebrafish -- Ecotoxicity Assays Using Freshwater Planarians -- Toxicogenomic Analysis -- Strategy Combining Non-Animal Methods for Ocular Toxicity Evaluation -- Immunocytochemistry Analysis of HepG2 Cell 3D Culture Encapsulated as Spheroids in Alginate Beads -- Oxygen Consumption Evaluation: An Important Indicator of Metabolic State, Cellular Function and Cell Fate Along Neural Deregulation -- Mitochondrial Bioenergetic Assays as a Standard Protocol for Toxicological and Metabolic Assessment -- In Vitro Apoptotic Cell Death Assessment.

This book collects protocols from different areas of knowledge to assist in the identification of toxic effects exerted by different xenobiotics. At the same time as classical techniques are presented, modern techniques with alternative models to the use of animals are also presented. Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Toxicity Assessment: Methods and Protocols aims to serve researchers in this vast field of science as they seek to better understand the mechanisms of action of different xenobiotics.

ISBN: 9781071610930EUR114.99Subjects--Topical Terms:

3565842
Toxicology
--Laboratory manuals.Index Terms--Genre/Form:

3565848
Laboratory Manual

LC Class. No.: RA1199

Dewey Class. No.: 610

National Library of Medicine Call No.: QV 602

Toxicity assessment : = methods and protocols /
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520 # $a This book collects protocols from different areas of knowledge to assist in the identification of toxic effects exerted by different xenobiotics. At the same time as classical techniques are presented, modern techniques with alternative models to the use of animals are also presented. Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Toxicity Assessment: Methods and Protocols aims to serve researchers in this vast field of science as they seek to better understand the mechanisms of action of different xenobiotics.
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