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Contributors. -- Foreword. -- Preface. -- Getting Started. -- Assessing Available Information. -- Organizing and Preliminary Planning for Surgical Research -- Writing a Protocol: Animals, Humans, and Use of Biologic, Chemical, and Radiologic Agents. -- Grantsmanship. -- Informed Consent and the Protection of Human Research Subjects: Historical Perspectives and Guide to Current United States Regulations. -- Animal Care and Maintenance. -- Funding Strategies and Agencies: Academic-Industrial Relationships; Intellectual Property. -- Statistical Considerations. -- Use of Nonexperimental Studies to Evaluate Surgical Procedures and Other Interventions: The Challenge of Risk Adjustment. -- Measuring Surgical Outcomes. -- Design of Clinical Trials. -- Using Administrative Data for Clinical Research. -- Research in the Intensive Care Unit: Ethical and Methodological Issues. -- Research in the Operating Room. -- Effects of Age and Gender. -- Strategies, Principles, and Techniques Using Transgenic and Knockout Mouse Models. -- Tissue Culture, Cell Growth, and Analysis. -- Hematopoietic Stem Cells: Basic Concepts and Applications to Surgical Research. -- Base Molecular Biological Methods in Surgical Research: Genetic Library Construction, Screening, and DNA Sequencing. -- Transcription. -- Signal Transduction and Apoptosis. -- Mechanisms and Regulation of Eukaryotic Protein Synthesis. -- Organelle Studies: Mitochondria, Golgi, and Endoplasmic Reticulum. -- Membrane Biology and Biophysics. -- Molecular Epidemiology: Beyond Gene Discovery to Clinical Diagnostic Tools. -- Shock Models: Hemorrhage. -- Scoring Systems for Trauma Research. -- Blunt Trauma Models: Fractures, Chest Trauma, Head Injury, Soft-Tissue Trauma, and Abdominal Trauma. -- Trauma Models for Studying the Influence of Gender and Aging. -- Animal Models of Burn Injury. -- Wound Care Models. -- Models of Adult Respiratory Distress Syndrome-Aspiration. -- Tumor Angiogenesis. -- Approaches to Adoptive Immunotherapy. -- Metastasis: Biology and Experimental Models. -- Cancer Genetics. -- Cancer Gene Therapy. -- Active Immunotherapy for Cancer. -- Gastrointestinal Motility. -- Models of Intestinal Secretion and Absorption. -- Surgical Models of Inflammatory Bowel Disease. -- Intestinal Regeneration and Adaptation Models. -- Minimally Invasive Surgery. -- Experimental Models and Endpoints for Studies of Intestinal Ischemia-Resperfusion Injury. -- Gut Barrier Failure. -- Developmental Studies in the Gastrointestinal Tract. -- Animal Models of Liver Failure. -- Portal Hypertension and Portacaval Shunt. -- Animal Models of Liver Regeneration. -- Animal Models for the Study of Hepatocyte Transplantation. -- Biliary Stone Formation. -- Models for the Study of Pancreatitis. -- Models of Endocrine Insufficiency. -- Animal Models in Transplantation. -- Models to Study Surgical Nutrition and Metabolism. -- Stable Isotopes. -- Body Composition. -- Energetics. -- Models of Protein Metabolism. -- Membrane Transport of Nutrients. -- Models of Wound Healing in Growth Factor Studies. -- Animal Models of Sepsis and the Multiple Organ Dysfunction Syndrome. -- The Immuno-Inflammatory Response. -- Antibiotic Trials. -- Scoring Systems for Sepsis and the Multiple Organ Dysfunction Syndrome. -- Cytokine Biology. -- Biology of Nitric Oxide: Measurement, Modulation, and Models. -- Endothelial Cell and Smooth Muscle Cell Biology in Vascular Disease. -- Coagulation Biology. -- Endovascular Research: Stents. -- Noninvasive Vascular Measurements. -- Techniques to Study Microcirculation. -- Blood Substitutes in Surgery. -- Research Models in Pediatric Surgery. -- Research in Fetal Surgery. -- Research in Plastic Surgery. -- Research Methods in Neurosurgery. -- Research in Urologic Surgery. -- Research in Cardiac Surgery. -- Research in Orthopedic Surgery. -- Statistical Analysis-Specific Statistical Tests: Indications for Use. -- Data Presentation: How to Write and Submit Abstracts and Papers. -- Audiovisual Communications as a Research Skill. -- Organizing and Managing Meetings and Conferences. -- The Management and Organization of a Surgical Research Laboratory. -- History and Philosophy of Surgical Research. -- The Surgical Research Program as a Business Enterprise. -- Nobel Laureates in Surgery. -- Surgical Education Research. -- Mathematical Modeling. -- Information Resource Discovery for Surgeons: Databases and the Internet. -- How to Review a Manuscript. -- Academic Surgical Mentoring. -- Ethics and Surgical Research. -- The National Institutes of Health: Procedures and Performance. -- Measuring the Performance of Surgical Research. -- Virtual Reality and Surgery. -- Surgeons and Health Services Research. -- From Idea to Product: Financing and Regulatory Issues in Product Development. |