東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ subject:"Proteins- Denaturation." ]

切換: 標籤 | MARC模式 | ISBD

The unfolded protein response in cancer

Clarke, Robert.

FindBook

Google Book

Amazon

博客來

The unfolded protein response in cancer

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The unfolded protein response in cancer/ edited by Robert Clarke.
其他作者:	Clarke, Robert.
出版者:	Cham :Springer International Publishing : : 2019.,
面頁冊數:	xi, 220 p. :ill. (some col.), digital ;24 cm.
內容註:	Introduction: The Unfolded Protein Response -- Endoplasmic Reticulum Stress Signaling During Development -- Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy -- ATF4, Hypoxia and Treatment Resistance in Cancer -- Role of Protein Translation in the Unfolded Protein Response -- Roles of Spliced and Unspliced XBP1 in Breast Cancer -- The Unfolded Protein Response in Triple-Negative Breast Cancer -- The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer -- Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling -- Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases -- Index.
Contained By:	Springer eBooks
標題:	Cancer - Molecular aspects. -
電子資源:	https://doi.org/10.1007/978-3-030-05067-2
ISBN:	9783030050672

The unfolded protein response in cancer
The unfolded protein response in cancer[electronic resource] /edited by Robert Clarke. - Cham :Springer International Publishing :2019. - xi, 220 p. :ill. (some col.), digital ;24 cm. - Cancer drug discovery and development,2196-9906. - Cancer drug discovery and development..

Introduction: The Unfolded Protein Response -- Endoplasmic Reticulum Stress Signaling During Development -- Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy -- ATF4, Hypoxia and Treatment Resistance in Cancer -- Role of Protein Translation in the Unfolded Protein Response -- Roles of Spliced and Unspliced XBP1 in Breast Cancer -- The Unfolded Protein Response in Triple-Negative Breast Cancer -- The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer -- Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling -- Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases -- Index.

This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.

ISBN: 9783030050672

Standard No.: 10.1007/978-3-030-05067-2doiSubjects--Topical Terms:

661419
Cancer
--Molecular aspects.

LC Class. No.: RC268.4

Dewey Class. No.: 616.99407

The unfolded protein response in cancer
LDR:02649nmm a2200337 a 4500 001 2180048
003 DE-He213
005 20190301180906.0
006 m d
007 cr nn 008maaau
008 191122s2019 gw s 0 eng d
020 $a 9783030050672 $q (electronic bk.)
020 $a 9783030050658 $q (paper)
024 7 $a 10.1007/978-3-030-05067-2 $2 doi
035 $a 978-3-030-05067-2
040 $a GP $c GP
041 0 $a eng
050 4 $a RC268.4
072 7 $a MJCL $2 bicssc
072 7 $a MED062000 $2 bisacsh
072 7 $a MJCL $2 thema
082 0 4 $a 616.99407 $2 23
090 $a RC268.4 $b .U56 2019
245 0 4 $a The unfolded protein response in cancer $h [electronic resource] / $c edited by Robert Clarke.
260 $a Cham : $b Springer International Publishing : $b Imprint: Humana Press, $c 2019.
300 $a xi, 220 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Cancer drug discovery and development, $x 2196-9906
505 0 $a Introduction: The Unfolded Protein Response -- Endoplasmic Reticulum Stress Signaling During Development -- Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy -- ATF4, Hypoxia and Treatment Resistance in Cancer -- Role of Protein Translation in the Unfolded Protein Response -- Roles of Spliced and Unspliced XBP1 in Breast Cancer -- The Unfolded Protein Response in Triple-Negative Breast Cancer -- The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer -- Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling -- Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases -- Index.
520 $a This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
650 0 $a Cancer $x Molecular aspects. $3 661419
650 0 $a Proteins $x Denaturation. $3 1001536
650 1 4 $a Cancer Research. $3 891172
700 1 $a Clarke, Robert. $3 3385753
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
830 0 $a Cancer drug discovery and development. $3 1565408
856 4 0 $u https://doi.org/10.1007/978-3-030-05067-2
950 $a Medicine (Springer-11650)