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Absorption and drug development = so...

Avdeef, Alex.

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Absorption and drug development = solubility, permeability, and charge state /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Absorption and drug development/ Alex Avdeef.
Reminder of title:	solubility, permeability, and charge state /
Author:	Avdeef, Alex.
Published:	Hoboken, N.J. :Wiley-Interscience, : c2003.,
Description:	1 online resource (xxiv, 287 p.) :ill.
Notes:	Wiley online library (ebook collection)
[NT 15003449]:	Cover -- CONTENTS -- PREFACE -- ACKNOWLEDGMENTS -- DEFINITIONS -- 1 INTRODUCTION -- 1.1 Shotgun Searching for Drugs? -- 1.2 Screen for the Target or ADME First? -- 1.3 ADME and Multimechanism Screens -- 1.4 ADME and Medicinal Chemists -- 1.5 The "A" in ADME -- 1.6 It is Not Just a Number"It is a Multimechanism -- 2 TRANSPORT MODEL -- 2.1 Permeability-Solubility-Charge State and the pH Partition Hypothesis -- 2.2 Properties of the Gastrointestinal Tract (GIT) -- 2.3 pH Microclimate -- 2.4 Intracellular pH Environment -- 2.5 Tight-Junction Complex -- 2.6 Structure of Octanol -- 2.7 Biopharmaceutics Classification System -- 3 CHARGE STATE -- 3.1 Constant Ionic Medium Reference State -- 3.2 pK(a) Databases -- 3.3 Potentiometric Measurements -- 3.3.1 Bjerrum Plots -- 3.3.2 pH Definitions and Electrode Standardization -- 3.3.3 The Solubility Problem'' and Cosolvent Methods -- 3.3.4 Use of Cosolvents for Water-Soluble Molecules -- 3.4 Spectrophotometric Measurements -- 3.5 Capillary Electrophoresis Measurements -- 3.6 Chromatographic pK(a) Measurement -- 3.7 pK(a) Microconstants -- 3.8 pK(a) "Gold Standard" for Drug Molecules -- 4 PARTITIONING INTO OCTANOL -- 4.1 Tetrad of Equilibria -- 4.2 Conditional Constants -- 4.3 log P Databases -- 4.4 log D -- 4.5 Partitioning of Quaternary Ammonium Drugs -- 4.6 log D of Multiprotic Drugs and the Common-Ion Effect -- 4.7 Summary of Charged-Species Partitioning in Octanol...Water -- 4.8 Ion Pair Absorption of Ionized Drugs"Fact or Fiction? -- 4.9 Micro-log P -- 4.10 HPLC Methods -- 4.11 IAM Chromatography -- 4.12 Liposome Chromatography -- 4.13 Other Chromatographic Methods -- 4.14 pH-Metric log P Method -- 4.15 High-Throughput log P Methods -- 4.16 Octanol...Water log P(N), log P(I), and log D(7.4) "Gold Standard" for Drug Molecules -- 5 PARTITIONING INTO LIPOSOMES -- 5.1 Tetrad of Equilibria and Surface Ion Pairing (SIP) -- 5.2 Databases -- 5.3 Location of Drugs Partitioned into Bilayers -- 5.4 Thermodynamics of Partitioning: En
Subject:	Drugs - Design. -
Online resource:	http://dx.doi.org/10.1002/047145026X
ISBN:	9781601193681 (electronic bk.)

Absorption and drug development = solubility, permeability, and charge state /
Avdeef, Alex.

Absorption and drug developmentsolubility, permeability, and charge state /[electronic resource] :Alex Avdeef. - Hoboken, N.J. :Wiley-Interscience,c2003. - 1 online resource (xxiv, 287 p.) :ill.

Wiley online library (ebook collection)

Includes bibliographical references (p. 250-284) and index.

Cover -- CONTENTS -- PREFACE -- ACKNOWLEDGMENTS -- DEFINITIONS -- 1 INTRODUCTION -- 1.1 Shotgun Searching for Drugs? -- 1.2 Screen for the Target or ADME First? -- 1.3 ADME and Multimechanism Screens -- 1.4 ADME and Medicinal Chemists -- 1.5 The "A" in ADME -- 1.6 It is Not Just a Number"It is a Multimechanism -- 2 TRANSPORT MODEL -- 2.1 Permeability-Solubility-Charge State and the pH Partition Hypothesis -- 2.2 Properties of the Gastrointestinal Tract (GIT) -- 2.3 pH Microclimate -- 2.4 Intracellular pH Environment -- 2.5 Tight-Junction Complex -- 2.6 Structure of Octanol -- 2.7 Biopharmaceutics Classification System -- 3 CHARGE STATE -- 3.1 Constant Ionic Medium Reference State -- 3.2 pK(a) Databases -- 3.3 Potentiometric Measurements -- 3.3.1 Bjerrum Plots -- 3.3.2 pH Definitions and Electrode Standardization -- 3.3.3 The Solubility Problem'' and Cosolvent Methods -- 3.3.4 Use of Cosolvents for Water-Soluble Molecules -- 3.4 Spectrophotometric Measurements -- 3.5 Capillary Electrophoresis Measurements -- 3.6 Chromatographic pK(a) Measurement -- 3.7 pK(a) Microconstants -- 3.8 pK(a) "Gold Standard" for Drug Molecules -- 4 PARTITIONING INTO OCTANOL -- 4.1 Tetrad of Equilibria -- 4.2 Conditional Constants -- 4.3 log P Databases -- 4.4 log D -- 4.5 Partitioning of Quaternary Ammonium Drugs -- 4.6 log D of Multiprotic Drugs and the Common-Ion Effect -- 4.7 Summary of Charged-Species Partitioning in Octanol...Water -- 4.8 Ion Pair Absorption of Ionized Drugs"Fact or Fiction? -- 4.9 Micro-log P -- 4.10 HPLC Methods -- 4.11 IAM Chromatography -- 4.12 Liposome Chromatography -- 4.13 Other Chromatographic Methods -- 4.14 pH-Metric log P Method -- 4.15 High-Throughput log P Methods -- 4.16 Octanol...Water log P(N), log P(I), and log D(7.4) "Gold Standard" for Drug Molecules -- 5 PARTITIONING INTO LIPOSOMES -- 5.1 Tetrad of Equilibria and Surface Ion Pairing (SIP) -- 5.2 Databases -- 5.3 Location of Drugs Partitioned into Bilayers -- 5.4 Thermodynamics of Partitioning: En

ISBN: 9781601193681 (electronic bk.)

Standard No.: 10.1002/047145026Xdoi

Knovel Corporationhttp://www.knovel.comSubjects--Topical Terms:

664528
Drugs
--Design.

LC Class. No.: RS420 / .A935 2003eb

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: 2003 L-690

Absorption and drug development = solubility, permeability, and charge state /
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588 $a Description based on print version record.
650 # 0 $a Drugs $x Design. $3 664528
650 # 0 $a Drugs $x Metabolism. $3 683549
650 # 0 $a Drug development. $3 716904
650 # 0 $a Absorption. $3 768291
650 1 2 $a Pharmaceutical Preparations $x metabolism. $3 600540
650 2 2 $a Administration, Oral. $3 916544
650 2 2 $a Pharmaceutical Preparations $x chemistry. $3 864709
650 2 2 $a Structure-Activity Relationship. $3 686451
650 # 6 $a Médicaments $x Conception. $3 2045387
650 # 6 $a Médicaments $x Métabolisme. $3 2045388
650 # 6 $a Médicaments $x Développement. $3 2045389
650 0 7 $a Arzneimittel. $2 swd $3 2045390
650 0 7 $a Verteilungskoeffizient. $2 swd $3 2045391
776 0 8 $i Print version: $a Avdeef, Alex. $t Absorption and drug development. $d Hoboken, N.J. : Wiley-Interscience, c2003 $z 0471423653 $w (DLC) 2003011397 $w (OCoLC)52295258
856 4 0 $u http://dx.doi.org/10.1002/047145026X