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Ion channels and disease = channelop...

Ashcroft, Frances M.{me_controlnum}

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Ion channels and disease = channelopathies /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Ion channels and disease/ Frances M. Ashcroft.
其他題名:	channelopathies /
作者:	Ashcroft, Frances M.{me_controlnum}
出版者:	San Diego :Academic Press, : c2000.,
面頁冊數:	xxi, 481 p. :ill. (some col.) ;26 cm.
內容註:	Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na⁺ Channels. -- Voltage-Gated K⁺ Channels. -- Ca-Activated K⁺ Channels. -- Inward Rectifier K⁺ Channels. -- Voltage-Gated Ca²⁺ Channels. -- Voltage-Gated Cl^- Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na⁺ Channels. -- Ligand-Gated Ca²⁺ Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index.
標題:	Ion channels. -
電子資源:	http://www.sciencedirect.com/science/book/9780120653102An electronic book accessible through the World Wide Web; click for information
ISBN:	9780120653102

Ion channels and disease = channelopathies /
Ashcroft, Frances M.{me_controlnum}

Ion channels and diseasechannelopathies /[electronic resource] :Frances M. Ashcroft. - San Diego :Academic Press,c2000. - xxi, 481 p. :ill. (some col.) ;26 cm.

Includes bibliographical references (p. 419-464) and index.

Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na+ Channels. -- Voltage-Gated K+ Channels. -- Ca-Activated K+ Channels. -- Inward Rectifier K+ Channels. -- Voltage-Gated Ca2+ Channels. -- Voltage-Gated Cl- Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na+ Channels. -- Ligand-Gated Ca2+ Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index.

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780120653102

Source: 77892:77892Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

656244
Ion channels.
Index Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: RB112.5 / .A83 2000eb

Dewey Class. No.: 616.07

National Agricultural Library Call No.: QH603.I54 / A84 2000

National Library of Medicine Call No.: 1999 K-445

Ion channels and disease = channelopathies /
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100 1 $a Ashcroft, Frances M.{me_controlnum} $3 1362005
245 1 0 $a Ion channels and disease $h [electronic resource] : $b channelopathies / $c Frances M. Ashcroft.
260 $a San Diego : $b Academic Press, $c c2000.
300 $a xxi, 481 p. : $b ill. (some col.) ; $c 26 cm.
504 $a Includes bibliographical references (p. 419-464) and index.
505 0 $a Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na+ Channels. -- Voltage-Gated K+ Channels. -- Ca-Activated K+ Channels. -- Inward Rectifier K+ Channels. -- Voltage-Gated Ca2+ Channels. -- Voltage-Gated Cl- Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na+ Channels. -- Ligand-Gated Ca2+ Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index.
520 $a Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2007. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on July 25, 2007). $n Access may be restricted to users at subscribing institutions.
650 0 $a Ion channels. $3 656244
650 0 $a Pathology, Molecular. $3 684620
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650 2 2 $a Genetic Diseases, Inborn $x physiopathology. $3 1362006
650 2 2 $a Membrane Proteins $x physiology. $3 868864
650 2 2 $a Metabolism, Inborn Errors $x physiopathology. $3 1362007
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994 $a C0 $b TEF