東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ subject:"Gene expression." ]

切換: 標籤 | MARC模式 | ISBD

Gene expression and its discontents ...

Wallace, Rodrick.

FindBook

Google Book

Amazon

博客來

Gene expression and its discontents = the social production of chronic disease /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Gene expression and its discontents/ by Rodrick Wallace, Deborah Wallace.
其他題名:	the social production of chronic disease /
作者:	Wallace, Rodrick.
其他作者:	Wallace, Deborah.
出版者:	Cham :Springer International Publishing : : 2016.,
面頁冊數:	xiii, 344 p. :ill., digital ;24 cm.
內容註:	Introduction -- 1. Toward new tools -- 2. Models of development -- 3. Groupoid symmetries -- 4. Epigenetic catalysis -- 5. Developmental disorders -- 6. An interim perspective -- 7. The obesity pandemic in the US -- 8. Coronary heart disease in the US -- 9. Cancer: a developmental perspective -- 10. Autoimmune disorders -- 11. Demoralization and obesity in Upper Manhattan -- 12. Death at an early age: AIDS and related mortality in New York City -- 13. Mental Disorders I: Western atomism and its culture-bound syndromes -- 14. Mental Disorders II: Psychopathology and sleep -- 15. Diabetes and Thyroid Cancer in Manhattan's Chinatown -- 16. Right-To-Work Laws and Alzheimer's Disease -- 17. Stress as an Environmental Exposure -- 18. Final Thoughts -- 19. Mathematical Appendix.
Contained By:	Springer eBooks
標題:	Epidemiology. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-48078-7
ISBN:	9783319480787

Gene expression and its discontents = the social production of chronic disease /
Wallace, Rodrick.

Gene expression and its discontentsthe social production of chronic disease /[electronic resource] :by Rodrick Wallace, Deborah Wallace. - 2nd ed. - Cham :Springer International Publishing :2016. - xiii, 344 p. :ill., digital ;24 cm.

Introduction -- 1. Toward new tools -- 2. Models of development -- 3. Groupoid symmetries -- 4. Epigenetic catalysis -- 5. Developmental disorders -- 6. An interim perspective -- 7. The obesity pandemic in the US -- 8. Coronary heart disease in the US -- 9. Cancer: a developmental perspective -- 10. Autoimmune disorders -- 11. Demoralization and obesity in Upper Manhattan -- 12. Death at an early age: AIDS and related mortality in New York City -- 13. Mental Disorders I: Western atomism and its culture-bound syndromes -- 14. Mental Disorders II: Psychopathology and sleep -- 15. Diabetes and Thyroid Cancer in Manhattan's Chinatown -- 16. Right-To-Work Laws and Alzheimer's Disease -- 17. Stress as an Environmental Exposure -- 18. Final Thoughts -- 19. Mathematical Appendix.

This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer's disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

ISBN: 9783319480787

Standard No.: 10.1007/978-3-319-48078-7doiSubjects--Topical Terms:

568544
Epidemiology.

LC Class. No.: QH450

Dewey Class. No.: 610

Gene expression and its discontents = the social production of chronic disease /
LDR:03314nmm a2200325 a 4500 001 2080523
003 DE-He213
005 20161124203554.0
006 m d
007 cr nn 008maaau
008 170616s2016 gw s 0 eng d
020 $a 9783319480787 $q (electronic bk.)
020 $a 9783319480770 $q (paper)
024 7 $a 10.1007/978-3-319-48078-7 $2 doi
035 $a 978-3-319-48078-7
040 $a GP $c GP
041 0 $a eng
050 4 $a QH450
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
082 0 4 $a 610 $2 23
090 $a QH450 $b .W193 2017
100 1 $a Wallace, Rodrick. $3 895122
245 1 0 $a Gene expression and its discontents $h [electronic resource] : $b the social production of chronic disease / $c by Rodrick Wallace, Deborah Wallace.
250 $a 2nd ed.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a xiii, 344 p. : $b ill., digital ; $c 24 cm.
505 0 $a Introduction -- 1. Toward new tools -- 2. Models of development -- 3. Groupoid symmetries -- 4. Epigenetic catalysis -- 5. Developmental disorders -- 6. An interim perspective -- 7. The obesity pandemic in the US -- 8. Coronary heart disease in the US -- 9. Cancer: a developmental perspective -- 10. Autoimmune disorders -- 11. Demoralization and obesity in Upper Manhattan -- 12. Death at an early age: AIDS and related mortality in New York City -- 13. Mental Disorders I: Western atomism and its culture-bound syndromes -- 14. Mental Disorders II: Psychopathology and sleep -- 15. Diabetes and Thyroid Cancer in Manhattan's Chinatown -- 16. Right-To-Work Laws and Alzheimer's Disease -- 17. Stress as an Environmental Exposure -- 18. Final Thoughts -- 19. Mathematical Appendix.
520 $a This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer's disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.
650 2 4 $a Epidemiology. $3 568544
650 2 4 $a Biochemistry, general. $3 890840
650 2 4 $a Computational Biology/Bioinformatics. $3 898313
650 2 4 $a Public Health. $3 624351
650 0 $a Gene expression. $3 643979
650 0 $a Chronic diseases. $3 520722
650 1 4 $a Biomedicine. $3 890831
650 2 4 $a Human Genetics. $3 891169
700 1 $a Wallace, Deborah. $3 1085019
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-48078-7
950 $a Biomedical and Life Sciences (Springer-11642)