東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ subject:"Drug Evaluation, Preclinical." ]

切換: 標籤 | MARC模式 | ISBD

Drug-like properties = concepts, str...

Kerns, Edward Harvel.{me_controlnum}

FindBook

Google Book

Amazon

博客來

Drug-like properties = concepts, structure design and methods : from ADME to toxicity optimization /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Drug-like properties/ Edward H. Kerns and Li Di.
其他題名:	concepts, structure design and methods : from ADME to toxicity optimization /
作者:	Kerns, Edward Harvel.{me_controlnum}
其他作者:	Di, Li.
出版者:	Amsterdam ;Academic Press, : c2008.,
面頁冊數:	xix, 526 p., [2] p. of plates :ill. (some col.) ;27 cm.
內容註:	Preface; Introductory Concepts; Physicochemical Properties; Disposition, Metabolism and Safety; Methods; Specific Topics; Answers to Problems; Appendix I: General References; Appendix II: Glossary.
標題:	Pharmaceutical chemistry. -
電子資源:	http://www.sciencedirect.com/science/book/9780123695208An electronic book accessible through the World Wide Web; click for information
ISBN:	9780123695208

Drug-like properties = concepts, structure design and methods : from ADME to toxicity optimization /
Kerns, Edward Harvel.{me_controlnum}

Drug-like propertiesconcepts, structure design and methods : from ADME to toxicity optimization /[electronic resource] :Edward H. Kerns and Li Di. - Amsterdam ;Academic Press,c2008. - xix, 526 p., [2] p. of plates :ill. (some col.) ;27 cm.

Includes bibliographical references (p. 492) and index.

Preface; Introductory Concepts; Physicochemical Properties; Disposition, Metabolism and Safety; Methods; Specific Topics; Answers to Problems; Appendix I: General References; Appendix II: Glossary.

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2008.

Mode of access: World Wide Web.

ISBN: 9780123695208

Source: 130415:130518Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

550956
Pharmaceutical chemistry.
Index Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: RS420 / .K47 2008eb

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: 2008 D-072

Drug-like properties = concepts, structure design and methods : from ADME to toxicity optimization /
LDR:03321cmm 2200349Ia 4500 001 1033710
003 OCoLC
005 20110615082930.0
006 m d
007 cr cn|||||||||
008 120420s2008 ne af ob 001 0 eng d
020 $a 9780123695208
020 $a 0123695201
029 1 $a NZ1 $b 13068804
035 $a (OCoLC)281596284
035 $a ocn281596284
037 $a 130415:130518 $b Elsevier Science & Technology $n http://www.sciencedirect.com
040 $a OPELS $b eng $c OPELS $d OPELS
049 $a TEFA
050 1 4 $a RS420 $b .K47 2008eb
060 1 4 $a 2008 D-072
060 1 4 $a QV 744 $b K395d 2008
082 0 4 $a 615/.19 $2 22
100 1 $a Kerns, Edward Harvel.{me_controlnum} $3 1364725
245 1 0 $a Drug-like properties $h [electronic resource] : $b concepts, structure design and methods : from ADME to toxicity optimization / $c Edward H. Kerns and Li Di.
260 $a Amsterdam ; $a Boston : $b Academic Press, $c c2008.
300 $a xix, 526 p., [2] p. of plates : $b ill. (some col.) ; $c 27 cm.
504 $a Includes bibliographical references (p. 492) and index.
505 0 $a Preface; Introductory Concepts; Physicochemical Properties; Disposition, Metabolism and Safety; Methods; Specific Topics; Answers to Problems; Appendix I: General References; Appendix II: Glossary.
520 $a Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2008. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Dec. 9, 2008). $n Access may be restricted to users at subscribing institutions.
650 0 $a Pharmaceutical chemistry. $3 550956
650 0 $a Drugs $x Structure-activity relationships. $3 686448
650 0 $a Drug development. $3 716904
650 0 $a Drugs $x Design. $3 664528
650 1 2 $a Drug Design. $3 550958
650 2 2 $a Drug Evaluation, Preclinical. $3 752567
650 2 2 $a Drug Toxicity. $3 813965
650 2 2 $a Pharmaceutical Preparations $x metabolism. $3 600540
650 2 2 $a Pharmacokinetics. $3 550960
650 2 2 $a Structure-Activity Relationship. $3 686451
655 7 $a Electronic books. $2 lcsh $3 542853
700 1 $a Di, Li. $3 885143
710 2 $a ScienceDirect (Online service) $3 848416
776 1 $c Original $z 9780123695208 $z 0123695201 $w (DLC) 2007035586 $w (OCoLC)169452881
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780123695208 $z An electronic book accessible through the World Wide Web; click for information
994 $a C0 $b TEF