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[ subject:"Chemistry, Analytical." ]
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Xerogel coatings for biomedical sens...
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The University of North Carolina at Chapel Hill., Chemistry.
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Xerogel coatings for biomedical sensing applications.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Xerogel coatings for biomedical sensing applications./
作者:
Dobmeier, Kevin Perry.
面頁冊數:
163 p.
附註:
Adviser: Mark H. Schoenfisch.
Contained By:
Dissertation Abstracts International68-11B.
標題:
Chemistry, Analytical. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3289125
ISBN:
9780549326977
Xerogel coatings for biomedical sensing applications.
Dobmeier, Kevin Perry.
Xerogel coatings for biomedical sensing applications.
- 163 p.
Adviser: Mark H. Schoenfisch.
Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2007.
New strategies for utilizing sol-gel chemistry to improve sensor compatibility with physiological environments and produce xerogel membranes for novel optical sensor applications are described. Incorporation of nitric oxide (NO)-donor functionalities into a material is an established means of creating more biocompatible blood and tissue-contacting surfaces. A NO-releasing optical pH sensor designed for intravascular use was developed through covalent attachment of N-diazeniumdiolate (NONOate) NO donors to aminoalkoxysilane-derived xerogels. A two-layer sensor configuration was employed wherein a NONOate-modified xerogel and porous tetramethyl orthosilicate xerogel containing a fluorescent pH indicator were sequentially dip-coated onto a tapered fiber-optic probe. The resulting sensors were capable of rapid and linear optical pH detection throughout the physiological pH range (7.0-7.8 pH) and generated NO fluxes >0.4 pmol cm-2 s-1 for ∼16 h. Significant reductions of platelet adhesion to the NO-releasing materials versus controls were observed after exposure to platelet-enriched porcine plasma.
ISBN: 9780549326977Subjects--Topical Terms:
586156
Chemistry, Analytical.
Xerogel coatings for biomedical sensing applications.
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New strategies for utilizing sol-gel chemistry to improve sensor compatibility with physiological environments and produce xerogel membranes for novel optical sensor applications are described. Incorporation of nitric oxide (NO)-donor functionalities into a material is an established means of creating more biocompatible blood and tissue-contacting surfaces. A NO-releasing optical pH sensor designed for intravascular use was developed through covalent attachment of N-diazeniumdiolate (NONOate) NO donors to aminoalkoxysilane-derived xerogels. A two-layer sensor configuration was employed wherein a NONOate-modified xerogel and porous tetramethyl orthosilicate xerogel containing a fluorescent pH indicator were sequentially dip-coated onto a tapered fiber-optic probe. The resulting sensors were capable of rapid and linear optical pH detection throughout the physiological pH range (7.0-7.8 pH) and generated NO fluxes >0.4 pmol cm-2 s-1 for ∼16 h. Significant reductions of platelet adhesion to the NO-releasing materials versus controls were observed after exposure to platelet-enriched porcine plasma.
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An alternate class of NO-releasing xerogels was formed by co-condensation of mercaptoalkoxysilane and alkylalkoxysilane sol-gel precursors. Subsequent thiol nitrosation resulted in S-nitrosothiol (RSNO)-modified xerogels capable of generating NO-fluxes >0.5 pmol cm-22 s -1 for up to 14 d in 37 °C phosphate-buffered saline (PBS). The films displayed excellent solution stability with larger percentages of NO-donor inclusion than NONOate-modified films. Reductions observed in platelet and Pseudomonas aeruginosa adhesion to nitrosated films versus non-nitrosated controls confirmed the antithrombotic and antibacterial properties of the materials.
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Aminoalkoxysilane-derived xerogels were further employed to create optical sensor coatings for quantitative detection of nitroxyl (HNO), the one-electron reduced congener of NO. A kinetic strategy was used to quantify HNO via the spectroscopically observed rates of HNO-induced reductive manganese(III) meso-tetrakis(4-sulfonatophenyl) porphyrinate (MnIIITPPS) nitrosylation. The stability of the MnII(NO)TPPS reaction product was significantly increased when encapsulated in the anaerobic interior of an (aminoethylaminomethyl)phenethyltrimethoxysilane (AEMP3)-derived xerogel film. Nitroxyl diffusion through the xerogel materials was selectively enhanced via the covalent incorporation of trimethoxysilyl-terminated poly(amidoamine-organosilicon) (PAMAMOS) dendrimers, resulting in substantially increased sensitivity to HNO. The HNO-sensing films were subsequently employed in a 96-well microtitre plate format to characterize HNO release from a recently described HNO/NO donor compound, sodium-1-(isopropylamino)diazene-1-ium-1,2-diolate (IPA/NO).
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3289125
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