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Social defeat stress, sensitization,...

Yap, Jasmine J.

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Social defeat stress, sensitization, and intravenous cocaine self-administration in mice.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Social defeat stress, sensitization, and intravenous cocaine self-administration in mice./
Author:	Yap, Jasmine J.
Description:	79 p.
Notes:	Adviser: Klaus A. Miczek.
Contained By:	Masters Abstracts International45-01.
Subject:	Psychology, Experimental. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1437710
ISBN:	9780542848377

Social defeat stress, sensitization, and intravenous cocaine self-administration in mice.
Yap, Jasmine J.

Social defeat stress, sensitization, and intravenous cocaine self-administration in mice. - 79 p.

Adviser: Klaus A. Miczek.

Thesis (M.S.)--Tufts University, 2006.

Indices of behavioral sensitization are thought to be based on neuroadaptive processes involved in addiction, and behavioral sensitization has been proposed as a process that is important in compulsive drug use and in psychotic disorders. In the following experiments, we examined the relationship between sensitization induced by social defeat stress and intravenous cocaine self-administration in mice, and compared this to the cocaine taking of amphetamine-sensitized mice. Male CFW mice were exposed either to defeat experiences, amphetamine (2.5 mg/kg, i.p.) or saline (i.p.) every day for 10 days. Ten days after the last defeat or injection, mice were challenged with varying doses of amphetamine (1.0-2.5 mg/kg i.p). Mice were then trained to nose-poke for intravenous cocaine (1.0 mg/kg/inf) during daily 3-hour sessions. Following this acquisition phase, the animals self-administered varying doses of cocaine (0.3-1.8 mg/kg/inf) or were allowed to self-administer cocaine (0.3 mg/kg/inf) according to a progressive ratio schedule of reinforcement. Repeated social defeat produced a sensitized motor response to a single challenge of 1.5 mg/kg amphetamine and to a cumulative dosing of amphetamine. Amphetamine-sensitized mice exhibited increased cocaine self-administration during acquisition and elevated break points during performance on a progressive ratio schedule of reinforcement relative to stress-sensitized and control animals. These data extend the evidence from rats to mice for the process of sensitization leading to more cocaine taking. Contrary to what is seen in rats, increased levels of cocaine self-administration were seen only in the amphetamine-sensitized mice and not after repeated defeat stress. While defeat stress-induced sensitization is detected up to 70 days after the last defeat in rats, this effect disappears after only 30 days in mice, suggesting that the sensitized response resulting from defeat stress may not be as long lasting or robust in this particular strain of mouse as it is in the rat.

ISBN: 9780542848377Subjects--Topical Terms:

517106
Psychology, Experimental.

Social defeat stress, sensitization, and intravenous cocaine self-administration in mice.
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100 1 $a Yap, Jasmine J. $3 1021879
245 1 0 $a Social defeat stress, sensitization, and intravenous cocaine self-administration in mice.
300 $a 79 p.
500 $a Adviser: Klaus A. Miczek.
500 $a Source: Masters Abstracts International, Volume: 45-01, page: 0492.
502 $a Thesis (M.S.)--Tufts University, 2006.
520 $a Indices of behavioral sensitization are thought to be based on neuroadaptive processes involved in addiction, and behavioral sensitization has been proposed as a process that is important in compulsive drug use and in psychotic disorders. In the following experiments, we examined the relationship between sensitization induced by social defeat stress and intravenous cocaine self-administration in mice, and compared this to the cocaine taking of amphetamine-sensitized mice. Male CFW mice were exposed either to defeat experiences, amphetamine (2.5 mg/kg, i.p.) or saline (i.p.) every day for 10 days. Ten days after the last defeat or injection, mice were challenged with varying doses of amphetamine (1.0-2.5 mg/kg i.p). Mice were then trained to nose-poke for intravenous cocaine (1.0 mg/kg/inf) during daily 3-hour sessions. Following this acquisition phase, the animals self-administered varying doses of cocaine (0.3-1.8 mg/kg/inf) or were allowed to self-administer cocaine (0.3 mg/kg/inf) according to a progressive ratio schedule of reinforcement. Repeated social defeat produced a sensitized motor response to a single challenge of 1.5 mg/kg amphetamine and to a cumulative dosing of amphetamine. Amphetamine-sensitized mice exhibited increased cocaine self-administration during acquisition and elevated break points during performance on a progressive ratio schedule of reinforcement relative to stress-sensitized and control animals. These data extend the evidence from rats to mice for the process of sensitization leading to more cocaine taking. Contrary to what is seen in rats, increased levels of cocaine self-administration were seen only in the amphetamine-sensitized mice and not after repeated defeat stress. While defeat stress-induced sensitization is detected up to 70 days after the last defeat in rats, this effect disappears after only 30 days in mice, suggesting that the sensitized response resulting from defeat stress may not be as long lasting or robust in this particular strain of mouse as it is in the rat.
590 $a School code: 0234.
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650 4 $a Psychology, Physiological. $3 1017869
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