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Effects of repeated morphine depriva...

Cooper, Ziva D.

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Effects of repeated morphine deprivation on operant responding in rats.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effects of repeated morphine deprivation on operant responding in rats./
Author:	Cooper, Ziva D.
Description:	144 p.
Notes:	Adviser: James H. Woods.
Contained By:	Dissertation Abstracts International68-02B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253247

Effects of repeated morphine deprivation on operant responding in rats.
Cooper, Ziva D.

Effects of repeated morphine deprivation on operant responding in rats. - 144 p.

Adviser: James H. Woods.

Thesis (Ph.D.)--University of Michigan, 2007.

These studies determined the effects of repeated morphine deprivation on behavior maintained by various reinforcers in the rat. A morphine dosing schedule was designed and characterized to establish and maintain dependence while allowing for repeated observation of behavior during morphine deprivation-induced withdrawal. Self-administration of the mu-opioid agonist remifentanil was assessed in nondependent (morphine-naive) rats and compared with self-administration in morphine dependent and deprived groups. Morphine deprivation was found to enhance remifentanil self-administration. The selectivity of this effect was assessed by evaluating the effects of morphine deprivation on behavior maintained by cocaine and two food reinforcers. Deprivation did not alter cocaine self-administration; however, deprivation did enhance behavior maintained by both food reinforcers. The increase in food-maintained behavior observed in the deprived group was likely due to morphine induced food deprivation and consequent weight loss throughout the experiment. Finally, to further characterize morphine deprivation-induced changes on the reinforcing effectiveness of remifentanil, economic demand was determined in dependent and nondependent groups of rats. Compared with nondependent rats, morphine-deprived rats demonstrated less elastic demand for remifentanil indicating that deprivation increased its reinforcing effectiveness. These studies provide evidence that morphine dependence and deprivation enhances the reinforcing properties of remifentanil.Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Effects of repeated morphine deprivation on operant responding in rats.
LDR:02394nam 2200265 a 45 001 972503
005 20110927
008 110927s2007 eng d
035 $a (UMI)AAI3253247
035 $a AAI3253247
040 $a UMI $c UMI
100 1 $a Cooper, Ziva D. $3 1296510
245 1 0 $a Effects of repeated morphine deprivation on operant responding in rats.
300 $a 144 p.
500 $a Adviser: James H. Woods.
500 $a Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 1355.
502 $a Thesis (Ph.D.)--University of Michigan, 2007.
520 $a These studies determined the effects of repeated morphine deprivation on behavior maintained by various reinforcers in the rat. A morphine dosing schedule was designed and characterized to establish and maintain dependence while allowing for repeated observation of behavior during morphine deprivation-induced withdrawal. Self-administration of the mu-opioid agonist remifentanil was assessed in nondependent (morphine-naive) rats and compared with self-administration in morphine dependent and deprived groups. Morphine deprivation was found to enhance remifentanil self-administration. The selectivity of this effect was assessed by evaluating the effects of morphine deprivation on behavior maintained by cocaine and two food reinforcers. Deprivation did not alter cocaine self-administration; however, deprivation did enhance behavior maintained by both food reinforcers. The increase in food-maintained behavior observed in the deprived group was likely due to morphine induced food deprivation and consequent weight loss throughout the experiment. Finally, to further characterize morphine deprivation-induced changes on the reinforcing effectiveness of remifentanil, economic demand was determined in dependent and nondependent groups of rats. Compared with nondependent rats, morphine-deprived rats demonstrated less elastic demand for remifentanil indicating that deprivation increased its reinforcing effectiveness. These studies provide evidence that morphine dependence and deprivation enhances the reinforcing properties of remifentanil.
590 $a School code: 0127.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Psychology, Psychobiology. $3 1017821
690 $a 0349
690 $a 0419
710 2 0 $a University of Michigan. $3 777416
773 0 $t Dissertation Abstracts International $g 68-02B.
790 $a 0127
790 1 0 $a Woods, James H., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253247