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Three-phase hybrid mixture theory fo...

Weinstein, Tessa F.

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Three-phase hybrid mixture theory for swelling drug delivery systems.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Three-phase hybrid mixture theory for swelling drug delivery systems./
Author:	Weinstein, Tessa F.
Description:	197 p.
Notes:	Adviser: Lynn S.Bennenthum.
Contained By:	Dissertation Abstracts International67-05B.
Subject:	Health Sciences, Pharmacy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3218092
ISBN:	9780542687419

Three-phase hybrid mixture theory for swelling drug delivery systems.
Weinstein, Tessa F.

Three-phase hybrid mixture theory for swelling drug delivery systems. - 197 p.

Adviser: Lynn S.Bennenthum.

Thesis (Ph.D.)--University of Colorado at Denver, 2006.

Drug delivery systems are composed of a polymeric carrier, such as hydroxypropyl methylcellulose (HPMC), and a drug or active agent, such as naproxen, the drug found in brands names such as Aleve. When such a device is ingested, the polymer swells and the pore-space increases in size, the drug diffuses out of the device. Some of these devices are swelling-controlled, meaning that the rate of swelling is the controlling factor in release kinetics. Modeling swelling-controlled polymeric drug delivery systems presents unique problems. As the solid drug undergoes phase transfer, the density of the solid phase, composed of polymer and drug, changes. As such, the usual incompressibility condition, that the density of the solid phase does not change in time, no longer applies. To overcome this difficulty we modify a two-phase mixture theoretic model to a three-phase model where the polymer and drug are modeled as separate solid phases, and the liquid phase remains water and drug. A two-scale and three-scale theory for such a three-phase model is developed. First, it is shown how a new choice of independent variables yields a physically meaningful interpretation of the solid phase stress, pressure, and Terzaghi stress tensors. We present the three-phase theory modeling the polymer as viscoelastic, the drug as elastic, and the liquid as a viscous fluid. We present constitutive theory, non-equilibrium results, equilibrium results, near-equilibrium results, as well as Darcy's and Fick's laws for both the two-scale and three-scale scenarios. Appropriate simplifications that are specifically applicable to swelling-controlled drug delivery systems are presented and used to combine the Darcy's and Fick's laws with the conservation of mass equations to obtain a system of equations which models the transport of the drug in terms of liquid volume fraction and the concentration of the drug in the liquid phase.

ISBN: 9780542687419Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Three-phase hybrid mixture theory for swelling drug delivery systems.
LDR:02812nam 2200277 a 45 001 971874
005 20110927
008 110927s2006 eng d
020 $a 9780542687419
035 $a (UnM)AAI3218092
035 $a AAI3218092
040 $a UnM $c UnM
100 1 $a Weinstein, Tessa F. $3 1295903
245 1 0 $a Three-phase hybrid mixture theory for swelling drug delivery systems.
300 $a 197 p.
500 $a Adviser: Lynn S.Bennenthum.
500 $a Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2599.
502 $a Thesis (Ph.D.)--University of Colorado at Denver, 2006.
520 $a Drug delivery systems are composed of a polymeric carrier, such as hydroxypropyl methylcellulose (HPMC), and a drug or active agent, such as naproxen, the drug found in brands names such as Aleve. When such a device is ingested, the polymer swells and the pore-space increases in size, the drug diffuses out of the device. Some of these devices are swelling-controlled, meaning that the rate of swelling is the controlling factor in release kinetics. Modeling swelling-controlled polymeric drug delivery systems presents unique problems. As the solid drug undergoes phase transfer, the density of the solid phase, composed of polymer and drug, changes. As such, the usual incompressibility condition, that the density of the solid phase does not change in time, no longer applies. To overcome this difficulty we modify a two-phase mixture theoretic model to a three-phase model where the polymer and drug are modeled as separate solid phases, and the liquid phase remains water and drug. A two-scale and three-scale theory for such a three-phase model is developed. First, it is shown how a new choice of independent variables yields a physically meaningful interpretation of the solid phase stress, pressure, and Terzaghi stress tensors. We present the three-phase theory modeling the polymer as viscoelastic, the drug as elastic, and the liquid as a viscous fluid. We present constitutive theory, non-equilibrium results, equilibrium results, near-equilibrium results, as well as Darcy's and Fick's laws for both the two-scale and three-scale scenarios. Appropriate simplifications that are specifically applicable to swelling-controlled drug delivery systems are presented and used to combine the Darcy's and Fick's laws with the conservation of mass equations to obtain a system of equations which models the transport of the drug in terms of liquid volume fraction and the concentration of the drug in the liquid phase.
590 $a School code: 0765.
650 4 $a Health Sciences, Pharmacy. $3 1017737
650 4 $a Mathematics. $3 515831
690 $a 0405
690 $a 0572
710 2 0 $a University of Colorado at Denver. $3 1018567
773 0 $t Dissertation Abstracts International $g 67-05B.
790 $a 0765
790 1 0 $a S.Bennenthum, Lynn, $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3218092