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Evaluating genetic testing for susce...

Lomax, Geoffrey Peter.

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Evaluating genetic testing for susceptibility to occupationally-induced disease: A case study of chronic beryllium disease.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Evaluating genetic testing for susceptibility to occupationally-induced disease: A case study of chronic beryllium disease./
Author:	Lomax, Geoffrey Peter.
Description:	144 p.
Notes:	Chair: Patricia A. Buffler.
Contained By:	Dissertation Abstracts International64-02B.
Subject:	Health Sciences, Occupational Health and Safety. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3082486
ISBN:	9780496303373

Evaluating genetic testing for susceptibility to occupationally-induced disease: A case study of chronic beryllium disease.
Lomax, Geoffrey Peter.

Evaluating genetic testing for susceptibility to occupationally-induced disease: A case study of chronic beryllium disease. - 144 p.

Chair: Patricia A. Buffler.

Thesis (Dr.P.H.)--University of California, Berkeley, 2002.

Advances in genetics permit the identification of genes affecting individual susceptibility to disease. One example is Chronic Beryllium Disease (CBD) which results from occupationally-related beryllium exposure. Research indicates that a portion of the occupationally-exposed population may be at high risk for CBD, and it may be possible to identify this sub-population through genetic testing.

ISBN: 9780496303373Subjects--Topical Terms:

1017799
Health Sciences, Occupational Health and Safety.

Evaluating genetic testing for susceptibility to occupationally-induced disease: A case study of chronic beryllium disease.
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035 $a (UMI)AAI3082486
035 $a AAI3082486
040 $a UMI $c UMI
100 1 $a Lomax, Geoffrey Peter. $3 1294795
245 1 0 $a Evaluating genetic testing for susceptibility to occupationally-induced disease: A case study of chronic beryllium disease.
300 $a 144 p.
500 $a Chair: Patricia A. Buffler.
500 $a Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0667.
502 $a Thesis (Dr.P.H.)--University of California, Berkeley, 2002.
520 $a Advances in genetics permit the identification of genes affecting individual susceptibility to disease. One example is Chronic Beryllium Disease (CBD) which results from occupationally-related beryllium exposure. Research indicates that a portion of the occupationally-exposed population may be at high risk for CBD, and it may be possible to identify this sub-population through genetic testing.
520 $a Beryllium-exposed workers at Los Alamos National Laboratory (LANL) participated in research which demonstrated a relationship between genetic factors and CBD risk raising the question of whether they should obtain their individual results. This question was evaluated using a Health Technology Assessment framework. Evaluation criteria are (1) scientific readiness, (2) legal and policy issues, (3) the ethicality of testing, and (4) social implications. In terms of scientific readiness, an association between genotype and CBD disease risk is observed in published studies. Testing meets standards of clinical utility because there are protective measures a beryllium-exposed worker could reasonably take. A worker's right-to-know information about their health is a core principle in occupational health law and policy. The law asserts that health examinations be voluntary and not be used to discriminate against workers. Ethical reasoning emphasizes autonomy and respect for persons which argues for notification because it permits workers to choose appropriate courses of action on the basis of relevant health information. The organizational context of a major national laboratory and worker contact with hazardous materials highlights the uncertainty that arises in the absence of a genetic testing and notification program. Testing and notification may reduce uncertainty and thus enhance trust among beryllium-exposed workers.
520 $a The major recommendations to LANL resulting from this research are: (1) beryllium-exposed worker participants in LANL-sponsored genetic research studies should have the opportunity to be notified voluntarily of their genetic test results; (2) results of genetic testing should not be disclosed to management; (3) the process of worker notification should be evaluated; (4) decisions to expand genetic testing and worker notification should be based on demonstrated evidence of effectiveness, and (5) further research needs to determine whether genetic testing can be used in conjunction with other methods to reduce the incidence of CBD.
590 $a School code: 0028.
650 4 $a Health Sciences, Occupational Health and Safety. $3 1017799
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0354
690 $a 0573
710 2 0 $a University of California, Berkeley. $3 687832
773 0 $t Dissertation Abstracts International $g 64-02B.
790 $a 0028
790 1 0 $a Buffler, Patricia A., $e advisor
791 $a Dr.P.H.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3082486