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The spectral response of the circadi...

Geusz, Michael Eric.

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The spectral response of the circadian pacemaker in the eye of the mollusk Bulla gouldiana.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The spectral response of the circadian pacemaker in the eye of the mollusk Bulla gouldiana./
Author:	Geusz, Michael Eric.
Description:	186 p.
Notes:	Director: Terry L. Page.
Contained By:	Dissertation Abstracts International51-02B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9017619

The spectral response of the circadian pacemaker in the eye of the mollusk Bulla gouldiana.
Geusz, Michael Eric.

The spectral response of the circadian pacemaker in the eye of the mollusk Bulla gouldiana. - 186 p.

Director: Terry L. Page.

Thesis (Ph.D.)--Vanderbilt University, 1989.

The eye of the mollusk Bulla gouldiana contains a pacemaker used in studies of the cellular basis of circadian rhythmicity. The pacemaker, which is believed to be composed of a population of basal retinal neurons (BRNs) located near the neuropil, generates a circadian rhythm in the frequency of large impulses in the optic nerve. Light pulses reset the phase of the pacemaker in eyes maintained in artificial seawater in constant darkness at 15$\sp\circSubjects--Topical Terms:

1017835
Biology, Animal Physiology.

The spectral response of the circadian pacemaker in the eye of the mollusk Bulla gouldiana.
LDR:03130nam 2200313 a 45 001 970728
005 20110921
008 110921s1989 eng d
035 $a (UMI)AAI9017619
035 $a AAI9017619
040 $a UMI $c UMI
100 1 $a Geusz, Michael Eric. $3 1294773
245 1 4 $a The spectral response of the circadian pacemaker in the eye of the mollusk Bulla gouldiana.
300 $a 186 p.
500 $a Director: Terry L. Page.
500 $a Source: Dissertation Abstracts International, Volume: 51-02, Section: B, page: 0598.
502 $a Thesis (Ph.D.)--Vanderbilt University, 1989.
520 $a The eye of the mollusk Bulla gouldiana contains a pacemaker used in studies of the cellular basis of circadian rhythmicity. The pacemaker, which is believed to be composed of a population of basal retinal neurons (BRNs) located near the neuropil, generates a circadian rhythm in the frequency of large impulses in the optic nerve. Light pulses reset the phase of the pacemaker in eyes maintained in artificial seawater in constant darkness at 15$\sp\circ $c . Evidence suggests that the BRNs are photosensitive, although the photopigments used in resetting the pacemaker are unknown.
520 $a In this study, the spectral sensitivity of both the immediate light response from the BRNs and the resetting of the pacemaker by light suggested that the photopigment used in resetting is a rhodopsin with maximal absorption near 490 nm. Eyes either in a light adapted state or treated to isolate the BRNs from input from other cells also showed the spectral sensitivity predicted for this rhodopsin. There was no evidence, from the spectral sensitivity results, that other photopigments are present in the eye.
520 $a Autofluorescence techniques and immunolocalization with polyclonal antibodies generated against vertebrate retinal proteins were used in attempts at identifying the photosensitive cells of the eye. An antibody specific for a bovine retinal-binding protein, which selectively binds the 11-cis isomer of retinal, labelled the distal photoreceptors in a concentration dependent manner, but was unable to detect retinal proteins in the BRNs. Rhodopsin and the photopigment retinochrome were detected in the distal photoreceptors by using autofluorescence techniques, but no discernable fluorescence from the photopigments could be found in the BRNs. These results suggested that the concentration of any rhodopsin in the BRNs may be much lower than in the distal photoreceptors.
520 $a A novel type of small photoinhibited impulse was recorded from whole and surgically reduced eyes, isolated segments of optic nerves, and from the optic nerve of nervous system preparations. In records from whole eyes, these impulses displayed a circadian rhythm in frequency that was about 12 hours out of phase with the CAP rhythm.
590 $a School code: 0242.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biophysics, General. $3 1019105
690 $a 0317
690 $a 0433
690 $a 0786
710 2 0 $a Vanderbilt University. $3 1017501
773 0 $t Dissertation Abstracts International $g 51-02B.
790 $a 0242
790 1 0 $a Page, Terry L., $e advisor
791 $a Ph.D.
792 $a 1989
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9017619