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Development of multi-parametric, hig...

Chen, Albert.

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Development of multi-parametric, high field magnetic resonance imaging techniques for improved characterization of prostate cancer.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Development of multi-parametric, high field magnetic resonance imaging techniques for improved characterization of prostate cancer./
Author:	Chen, Albert.
Description:	97 p.
Notes:	Adviser: Daniel B. Vigneron.
Contained By:	Dissertation Abstracts International67-05B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3221154
ISBN:	9780542708671

Development of multi-parametric, high field magnetic resonance imaging techniques for improved characterization of prostate cancer.
Chen, Albert.

Development of multi-parametric, high field magnetic resonance imaging techniques for improved characterization of prostate cancer. - 97 p.

Adviser: Daniel B. Vigneron.

Thesis (Ph.D.)--University of California, San Francisco, 2006.

The multi-parameric approach of acquiring different and unique MR data to characterize prostate cancer developed in this work may increase the usefulness and significance of MR prostate exam for the clinical management of prostate cancer.

ISBN: 9780542708671Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Development of multi-parametric, high field magnetic resonance imaging techniques for improved characterization of prostate cancer.
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020 $a 9780542708671
035 $a (UMI)AAI3221154
035 $a AAI3221154
040 $a UMI $c UMI
100 1 $a Chen, Albert. $3 1294680
245 1 0 $a Development of multi-parametric, high field magnetic resonance imaging techniques for improved characterization of prostate cancer.
300 $a 97 p.
500 $a Adviser: Daniel B. Vigneron.
500 $a Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2685.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2006.
520 $a The multi-parameric approach of acquiring different and unique MR data to characterize prostate cancer developed in this work may increase the usefulness and significance of MR prostate exam for the clinical management of prostate cancer.
520 $a Management of prostate cancer is a difficult task for both patients and clinicians because of the broad range of biologic malignancy and the broad spectrum of treatment approaches. Accurate radiological assessments are required for therapeutic selection and guidance, following patients on watchful waiting, monitoring treatment response in individual patients and for clinical trials of emerging therapies. In this bioengineering study, magnetic resonance (MR) techniques for metabolic and morphological assessments were developed and optimized specifically for prostate cancer and higher field (3T) to improve the non-invasive characterization of the disease.
520 $a At 3T, issues such as the J-modulation changes for citrate resonance at higher field, more severe magnetic susceptibility induced magnetic field inhomogeneities, and increased chemical shift mis-registration make robust acquisition and analysis of multi-parametric prostate MR data challenging. In this work, 3T prostate MR coils were developed and MR imaging sequences were optimized for acquisition of high-resolution anatomical images of the prostate. A new MLEV-Point RESolved Spectroscopy (MLEV-PRESS) sequence was developed to allow acquisition of up-right citrate resonance at 3T. High resolution (0.157cc) MR spectroscopic imaging (MRSI) data were acquired at 3T and the theoretical 2-fold increase in SNR over 1.5T was demonstrated. To reduce the scan time of MRSI to allow acquisition of other MR modality during one clinical exam, a new, fast and robust MRSI acquisition utilizing flyback echo-planar readout trajectories was also developed. High quality data were demonstrated within half of the scan time required for conventional MRSI acquisition. For acquisition of prostate MR data based on movement of water and tissue micro-environment to reflect morphological changes in prostate cancer, single-shot fast spin-echo diffusion tensor imaging (SSFSE-DTI) sequence and magnetization prepared sequence with multi-slice spiral imaging for were optimized for prostate DTI and T2 relaxation parameter mapping. Significantly different diffusion and T2 relaxation parameters were observed in regions of prostate cancer as compared to normal prostate peripheral zone.
590 $a School code: 0034.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0541
690 $a 0574
710 2 0 $a University of California, San Francisco. $3 1025118
773 0 $t Dissertation Abstracts International $g 67-05B.
790 $a 0034
790 1 0 $a Vigneron, Daniel B., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3221154