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Signaling mechanisms and neutrophil ...

Lin, Phoebe.

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Signaling mechanisms and neutrophil modulation through the lysophosphatidylcholine receptor, G2A.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Signaling mechanisms and neutrophil modulation through the lysophosphatidylcholine receptor, G2A./
Author:	Lin, Phoebe.
Description:	137 p.
Notes:	Adviser: Richard D. Ye.
Contained By:	Dissertation Abstracts International67-05B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3218785
ISBN:	9780542701498

Signaling mechanisms and neutrophil modulation through the lysophosphatidylcholine receptor, G2A.
Lin, Phoebe.

Signaling mechanisms and neutrophil modulation through the lysophosphatidylcholine receptor, G2A. - 137 p.

Adviser: Richard D. Ye.

Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2006.

G2A is a lysophospholipid receptor found only in tissues of hematopoietic origin. Its G protein coupling profile and effects on neutrophil function were examined in detail.

ISBN: 9780542701498Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Signaling mechanisms and neutrophil modulation through the lysophosphatidylcholine receptor, G2A.
LDR:02043nam 2200301 a 45 001 970641
005 20110921
008 110921s2006 eng d
020 $a 9780542701498
035 $a (UMI)AAI3218785
035 $a AAI3218785
040 $a UMI $c UMI
100 1 $a Lin, Phoebe. $3 1294679
245 1 0 $a Signaling mechanisms and neutrophil modulation through the lysophosphatidylcholine receptor, G2A.
300 $a 137 p.
500 $a Adviser: Richard D. Ye.
500 $a Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2494.
502 $a Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2006.
520 $a G2A is a lysophospholipid receptor found only in tissues of hematopoietic origin. Its G protein coupling profile and effects on neutrophil function were examined in detail.
520 $a It was found that G2A couples constitutively to Galphas, Galphaq, and Galpha13. Its endogenously produced lipid ligand, lysophosphatidylcholine (LPC), also stimulated the Gas pathway resulting in a further elevation of cyclic adenosine monophosphate (CAMP). The phenotypic effect of this combination of G proteins activated by this receptor culminates in apoptosis of G2A-expressing cells, including a transfected cell line, and lymphocytes, which express G2A endogenously.
520 $a LPC stimulation of neutrophils, which also express G2A endogenously, had an inhibitory effect. LPC inhibited neutrophil superoxide generation, chemotaxis, degranulation, and neutrophil-mediated tissue damage as shown in an ex vivo mouse lung model of tissue reperfusion injury. This cumulative effect suggests that LPC, perhaps through its action on the receptor, G2A, plays a regulatory role in the control of neutrophil function.
590 $a School code: 0806.
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0419
690 $a 0982
710 2 0 $a University of Illinois at Chicago, Health Sciences Center. $3 1021703
773 0 $t Dissertation Abstracts International $g 67-05B.
790 $a 0806
790 1 0 $a Ye, Richard D., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3218785