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Regulators of pro-inflammatory neuro...

Bucelli, Robert Charles.

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Regulators of pro-inflammatory neuropeptide expression in sensory neurons.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Regulators of pro-inflammatory neuropeptide expression in sensory neurons./
Author:	Bucelli, Robert Charles.
Description:	196 p.
Notes:	Adviser: Dennis M. Higgins.
Contained By:	Dissertation Abstracts International67-04B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3213883
ISBN:	9780542630859

Regulators of pro-inflammatory neuropeptide expression in sensory neurons.
Bucelli, Robert Charles.

Regulators of pro-inflammatory neuropeptide expression in sensory neurons. - 196 p.

Adviser: Dennis M. Higgins.

Thesis (Ph.D.)--State University of New York at Buffalo, 2005.

Statins, a class of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are widely used in the primary and secondary prevention of coronary artery disease. Many of the clinical benefits associated with statin treatment were initially attributed to their effects on plasma lipids. However, in recent years it has become clear that the effects of statins are not limited to the cardiovascular benefits resulting from decreased serum low-density lipoprotein levels. Among the "pleiotropic effects" attributed to statins are improvement of endothelial dysfunction, antioxidant effects, anti-inflammatory effects, and stabilization of atherosclerotic plaques. In addition, there is suggestive evidence that statins may alleviate the neuroinflammation of multiple sclerosis, and Alzheimer's disease. The potential anti-neuroinflammatory actions of statins have focused on pathologies of the central nervous system but very little attention has been given to statins and inflammatory processes involving the peripheral nervous system. Along with immunocytes, somatic sensory neurons fulfill a major role in most forms of peripheral inflammation. The release of two neuropeptides expressed by sensory neurons, calcitonin gene-related peptide (CGRP) and substance P, results in neurogenic inflammation, a phenomenon which underlies the pathophysiological processes of diverse diseases such as migraine headache, rheumatoid arthritis, reactive airway disease, and chronic pain.

ISBN: 9780542630859Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Regulators of pro-inflammatory neuropeptide expression in sensory neurons.
LDR:03473nam 2200301 a 45 001 970628
005 20110921
008 110921s2005 eng d
020 $a 9780542630859
035 $a (UMI)AAI3213883
035 $a AAI3213883
040 $a UMI $c UMI
100 1 $a Bucelli, Robert Charles. $3 1294667
245 1 0 $a Regulators of pro-inflammatory neuropeptide expression in sensory neurons.
300 $a 196 p.
500 $a Adviser: Dennis M. Higgins.
500 $a Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1844.
502 $a Thesis (Ph.D.)--State University of New York at Buffalo, 2005.
520 $a Statins, a class of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are widely used in the primary and secondary prevention of coronary artery disease. Many of the clinical benefits associated with statin treatment were initially attributed to their effects on plasma lipids. However, in recent years it has become clear that the effects of statins are not limited to the cardiovascular benefits resulting from decreased serum low-density lipoprotein levels. Among the "pleiotropic effects" attributed to statins are improvement of endothelial dysfunction, antioxidant effects, anti-inflammatory effects, and stabilization of atherosclerotic plaques. In addition, there is suggestive evidence that statins may alleviate the neuroinflammation of multiple sclerosis, and Alzheimer's disease. The potential anti-neuroinflammatory actions of statins have focused on pathologies of the central nervous system but very little attention has been given to statins and inflammatory processes involving the peripheral nervous system. Along with immunocytes, somatic sensory neurons fulfill a major role in most forms of peripheral inflammation. The release of two neuropeptides expressed by sensory neurons, calcitonin gene-related peptide (CGRP) and substance P, results in neurogenic inflammation, a phenomenon which underlies the pathophysiological processes of diverse diseases such as migraine headache, rheumatoid arthritis, reactive airway disease, and chronic pain.
520 $a Bone morphogenetic proteins (BMPs) and activins (ACTs) are members of the transforming growth factor-beta TGF-beta) superfamily. They are among the few factors known to regulate CGRP and substance P expression in sensory neurons, during development and in adulthood. The current study explores the effects of statins on BMP-induced expression of inflammatory neuropeptides in rat sensory neurons. Statins inhibited BMP and ACT-induced neuropeptide expression at both the mRNA and protein levels, in rat sensory neurons cultured in serum free media. The inhibitory effect of lovastatin seemed specific to neuropeptide expression in that maximally effective concentrations of lovastatin had no effect on cell number or on the expression of other proteins including phosphorylated neurofilaments, Smad1, and alpha-tubulin. The statin inhibitory effect was a function of HMG-CoA reductase inhibition because it was reversed by mevalonate, the immediate downstream product of HMG-CoA reductase, and cholesterol supplementation. (Abstract shortened by UMI.)
590 $a School code: 0656.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0317
690 $a 0419
690 $a 0982
710 2 0 $a State University of New York at Buffalo. $3 1017814
773 0 $t Dissertation Abstracts International $g 67-04B.
790 $a 0656
790 1 0 $a Higgins, Dennis M., $e advisor
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3213883