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The effects of R(+)-lipoic and acid ...

Staples, Elizabeth M.

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The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase./
作者:	Staples, Elizabeth M.
面頁冊數:	91 p.
附註:	Source: Masters Abstracts International, Volume: 44-04, page: 1832.
Contained By:	Masters Abstracts International44-04.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR10762
ISBN:	9780494107621

The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase.
Staples, Elizabeth M.

The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase. - 91 p.

Source: Masters Abstracts International, Volume: 44-04, page: 1832.

Thesis (M.Sc.)--Brock University (Canada), 2006.

This thesis investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 +/- 0.67 yr, body mass, 78.7 +/- 10.3 kg, n=9). In certain individuals, lipoic acid decreased the 180-min area under the glucose concentration and insulin concentration curve during an oral glucose tolerance test (OGTT) (n=4). In the same individuals, lipoic acid supplementation decreased pyruvate dehydrogenase kinase activity (PDK) (0.09 +/- 0.024 min-1 vs. 0.137 +/- 0.023 min-1, n=4). The fasting levels of the activated form of pyruvate dehydrogenase (PDHa) were decreased following lipoic acid (0.42 +/- 0.13 mmol·min-1·kg-1 vs. 0.82 +/- 0.32 mmol·min-1·kg-1 , n=4), yet increased to a greater extent during the OGTT (1.21 +/- 0.34 mmol·min-1·kg-1 vs. 0.81 +/- 0.13 mmol·min-1·kg -1, n=4) following lipoic acid supplementation. No changes were demonstrated in the remaining subjects (n=5). It was concluded that improved glucose clearance during an OGTT following lipoic acid supplementation is assisted by increased muscle glucose oxidation through increased PDHa activation and decreased PDK activity in certain individuals.

ISBN: 9780494107621Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase.
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245 1 4 $a The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase.
300 $a 91 p.
500 $a Source: Masters Abstracts International, Volume: 44-04, page: 1832.
502 $a Thesis (M.Sc.)--Brock University (Canada), 2006.
520 $a This thesis investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 +/- 0.67 yr, body mass, 78.7 +/- 10.3 kg, n=9). In certain individuals, lipoic acid decreased the 180-min area under the glucose concentration and insulin concentration curve during an oral glucose tolerance test (OGTT) (n=4). In the same individuals, lipoic acid supplementation decreased pyruvate dehydrogenase kinase activity (PDK) (0.09 +/- 0.024 min-1 vs. 0.137 +/- 0.023 min-1, n=4). The fasting levels of the activated form of pyruvate dehydrogenase (PDHa) were decreased following lipoic acid (0.42 +/- 0.13 mmol·min-1·kg-1 vs. 0.82 +/- 0.32 mmol·min-1·kg-1 , n=4), yet increased to a greater extent during the OGTT (1.21 +/- 0.34 mmol·min-1·kg-1 vs. 0.81 +/- 0.13 mmol·min-1·kg -1, n=4) following lipoic acid supplementation. No changes were demonstrated in the remaining subjects (n=5). It was concluded that improved glucose clearance during an OGTT following lipoic acid supplementation is assisted by increased muscle glucose oxidation through increased PDHa activation and decreased PDK activity in certain individuals.
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