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Synthesis and characterization of bo...

Degoricija, Lovorka.

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Synthesis and characterization of bola-type dendritic macromolecules for use in biomedical applications.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Synthesis and characterization of bola-type dendritic macromolecules for use in biomedical applications./
Author:	Degoricija, Lovorka.
Description:	212 p.
Notes:	Adviser: Mark W. Grinstaff.
Contained By:	Dissertation Abstracts International67-11B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3240617
ISBN:	9780542960802

Synthesis and characterization of bola-type dendritic macromolecules for use in biomedical applications.
Degoricija, Lovorka.

Synthesis and characterization of bola-type dendritic macromolecules for use in biomedical applications. - 212 p.

Adviser: Mark W. Grinstaff.

Thesis (Ph.D.)--Boston University, 2007.

Dendrimers are well defined, highly branched macromolecules that consist of a core, internal branching units and a multitude of peripheral groups. Dendrimers possess low viscosities, high solubilities, single molecular weights, and a globular shape in solution. As a result, the architecture and physiochemical properties of dendrimers offer specific advantages over linear polymers.

ISBN: 9780542960802Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Synthesis and characterization of bola-type dendritic macromolecules for use in biomedical applications.
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020 $a 9780542960802
035 $a (UMI)AAI3240617
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040 $a UMI $c UMI
100 1 $a Degoricija, Lovorka. $3 1291877
245 1 0 $a Synthesis and characterization of bola-type dendritic macromolecules for use in biomedical applications.
300 $a 212 p.
500 $a Adviser: Mark W. Grinstaff.
500 $a Source: Dissertation Abstracts International, Volume: 67-11, Section: B, page: 6429.
502 $a Thesis (Ph.D.)--Boston University, 2007.
520 $a Dendrimers are well defined, highly branched macromolecules that consist of a core, internal branching units and a multitude of peripheral groups. Dendrimers possess low viscosities, high solubilities, single molecular weights, and a globular shape in solution. As a result, the architecture and physiochemical properties of dendrimers offer specific advantages over linear polymers.
520 $a Currently, millions of people in the Unites States seek treatment for the repair of corneal wounds. The standard of care for repairing these wounds involves using sutures, which do not actively participate in healing of the surgical procedure. Another common medical problem involves the degradation of cartilage due to osteoarthritis or trauma. Since cartilage has a limited capacity for self-repair, the current methods of treatment involve the use of non-surgical and/or surgical techniques to reduce pain while maintaining joint function. Consequently, there is interest in synthesizing dendritic macromolecules specifically for these biomedical applications.
520 $a Fourth generation, bola-type dendritic macromolecules were synthesized by the divergent method in an iterative process of monomer unit coupling, followed by deprotection. The design of these dendritic macromolecules was based on an ABA triblock architecture, wherein two dendritic arms, or A blocks, flanked a linear linker, or B block, via ester linkages. The dendritic arms consisted of biocompatible materials, while the linear linker was a non-immunogenic poly(ethylene glycol) of three different molecular weights. Degradation of these macromolecules leads to natural metabolites, such as succinic acid and glycerol, thus they are termed biodendritic macromolecules. The same synthetic strategy was used to prepare biodendritic macromolecules containing carbamate linkages, in addition to previous ester linkages, to obtain materials with a different set of physical properties.
520 $a Further functionalization of these macromolecules was needed to prepare photocrosslinkable systems for the formation of hydrated networks, or hydrogels. Forming hydrogel networks from highly branched biodendritic macromers offers advantages in preparing hydrogels at low polymer concentration, varying mechanical properties, and developing in situ polymerizing systems for delivery to an irregularly shaped wound site. Consequently, hydrogels based on macromolecules possessing ester linkages were explored as sealants for corneal wounds, while scaffolds for cartilage repair were prepared from macromolecules containing carbamate linkages.
590 $a School code: 0017.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0495
690 $a 0541
710 2 0 $a Boston University. $3 1017454
773 0 $t Dissertation Abstracts International $g 67-11B.
790 $a 0017
790 1 0 $a Grinstaff, Mark W., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3240617