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Immune defense variation and invasio...

Lee, Kelly A.

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Immune defense variation and invasion success in sparrows of the genus Passer.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Immune defense variation and invasion success in sparrows of the genus Passer./
作者:	Lee, Kelly A.
面頁冊數:	112 p.
附註:	Adviser: Martin Wikelski.
Contained By:	Dissertation Abstracts International67-02B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3208872
ISBN:	9780542570728

Immune defense variation and invasion success in sparrows of the genus Passer.
Lee, Kelly A.

Immune defense variation and invasion success in sparrows of the genus Passer. - 112 p.

Adviser: Martin Wikelski.

Thesis (Ph.D.)--Princeton University, 2006.

Overall, these comparative studies of the immune defenses of introduced and native Passer sparrows suggest that immune defense strategies could provide insight into the factors shaping biological invasions.

ISBN: 9780542570728Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Immune defense variation and invasion success in sparrows of the genus Passer.
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520 $a Overall, these comparative studies of the immune defenses of introduced and native Passer sparrows suggest that immune defense strategies could provide insight into the factors shaping biological invasions.
520 $a Introduced species leave behind native parasites and pathogens and encounter new ones. How non-native populations respond immunologically to a shift in natural enemies might influence their ability to invade. In particular, the risk of inappropriate inflammatory responses might increase when there is an evolutionary mismatch between host and pathogen, and such harmful responses could ultimately slow or prevent invasion. I hypothesized that invaders should rely more heavily on antibody-mediated defenses against novel pathogens, and exhibit dampened inflammatory responses. This leads to the predictions that successful invaders should have attenuated inflammatory responses and stronger humoral defenses compared with both poor invaders and with their ancestral populations. Here I begin to address these predictions using Passer sparrows introduced into North America as a model system. I conducted two studies, the first comparing immune responses of the invasive house sparrow (P. domesticus) and its less invasive congener, the tree sparrow (P. montanus), and the second comparing systemic inflammatory responses in native and introduced house sparrows. With the first study I found support for both predictions: invasive house sparrows had lower behavioral and reproductive responses to inflammatory challenges than did less invasive tree sparrows; and house sparrows mounted stronger specific antibody responses. The second study provided further support for the hypothesis that reduced systemic inflammation should be favored in invaders; introduced house sparrows challenged with an inflammatory agent consistently showed little or no change in locomotor activity, food intake, or the acute phase protein lysozyme, while native house sparrows exhibited classical sickness behaviors and increased lysozyme levels. Interestingly, a second acute phase protein, alpha 1-acid glycoprotein (AGP), increased to a greater degree in introduced sparrows than in native sparrows. This observation could provide a clue to the mechanism underlying differences in inflammatory responses between house sparrows in North America and Europe, because AGP has important anti-inflammatory properties. Thus highly inducible AGP in introduced sparrows could be part of a tightly controlled response to inflammatory stimuli.
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