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Capillary electrophoresis for thermo...

Newman, Carl I. D.

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Capillary electrophoresis for thermodynamic and kinetic studies.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Capillary electrophoresis for thermodynamic and kinetic studies./
作者:	Newman, Carl I. D.
面頁冊數:	278 p.
附註:	Adviser: Victoria L. McGuffin.
Contained By:	Dissertation Abstracts International67-05B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3216160
ISBN:	9780542686832

Capillary electrophoresis for thermodynamic and kinetic studies.
Newman, Carl I. D.

Capillary electrophoresis for thermodynamic and kinetic studies. - 278 p.

Adviser: Victoria L. McGuffin.

Thesis (Ph.D.)--Michigan State University, 2006.

Capillary electrophoresis (CE) is a technique in which the individual components of complex mixtures can be separated based upon their physical characteristics of size and electrical charge. This work details the theoretical and instrumental development, simulation, validation, application, and limitations of capillary electrophoresis for investigating interactions between solute molecules.

ISBN: 9780542686832Subjects--Topical Terms:

586156
Chemistry, Analytical.

Capillary electrophoresis for thermodynamic and kinetic studies.
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020 $a 9780542686832
035 $a (UMI)AAI3216160
035 $a AAI3216160
040 $a UMI $c UMI
100 1 $a Newman, Carl I. D. $3 1291241
245 1 0 $a Capillary electrophoresis for thermodynamic and kinetic studies.
300 $a 278 p.
500 $a Adviser: Victoria L. McGuffin.
500 $a Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2523.
502 $a Thesis (Ph.D.)--Michigan State University, 2006.
520 $a Capillary electrophoresis (CE) is a technique in which the individual components of complex mixtures can be separated based upon their physical characteristics of size and electrical charge. This work details the theoretical and instrumental development, simulation, validation, application, and limitations of capillary electrophoresis for investigating interactions between solute molecules.
520 $a In order to understand the evolution of zone profiles in reactive CE, a series of stochastic (Monte Carlo) simulations were employed. These simulations were used to systematically investigate the effects of equilibrium constant, characteristic reaction lifetime, and electrophoretic mobility difference on zone profiles. Statistical moments were used to calculate the figures of merit velocity, plate height, and asymmetry of each zone profile. It was shown that the equilibrium constants are directly related to zone velocity; whereas, kinetic rate constants are directly related to zone plate height.
520 $a Using conclusions drawn from the simulation studies, a theoretical description is developed of the effects of reaction on velocity and plate height in capillary electrophoresis. The developed equations are validated with the simulations performed previously. The equations for velocity and plate height are also validated by investigating peptidyl-proline isomerizations that have been studied previously. These isomerizations exemplify first-order reactions and are notorious for slow rate constants. Calculated values for equilibrium constants and rate constants are shown to be in good agreement with previously published values.
520 $a The plate height model is also applied to the reversible, second-order inclusion of dansyl phenylalanine by beta-cyclodextrin. Although equilibrium or binding constants with beta-cyclodextrin have been reported previously, rate constants have remained elusive. The plate height model is used to calculate equilibrium constants and rate constants from the effects of beta-cyclodextrin concentration on velocity and plate height, respectively. The effect of temperature on equilibrium constant is used to calculate molar enthalpy and molar entropy. The calculated thermodynamic quantities are in agreement with previously published values. However, it was concluded that the rate constants for this reaction are too rapid for accurate evaluation via the plate height model. In light of this unsuccessful application, the influence of the physical properties of the instrumentation and of the solutes on the maximum calculable rate constants is discussed. (Abstract shortened by UMI.)
590 $a School code: 0128.
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0486
710 2 0 $a Michigan State University. $3 676168
773 0 $t Dissertation Abstracts International $g 67-05B.
790 $a 0128
790 1 0 $a McGuffin, Victoria L., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3216160