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Quantitative genetics of dengue-2 in...

Schneider, Jennifer R.

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Quantitative genetics of dengue-2 infection and body size in laboratory and Trinidad field populations of Aedes aegypti.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Quantitative genetics of dengue-2 infection and body size in laboratory and Trinidad field populations of Aedes aegypti./
Author:	Schneider, Jennifer R.
Description:	87 p.
Notes:	Adviser: David W. Severson.
Contained By:	Dissertation Abstracts International67-07B.
Subject:	Biology, Entomology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3227775
ISBN:	9780542809262

Quantitative genetics of dengue-2 infection and body size in laboratory and Trinidad field populations of Aedes aegypti.
Schneider, Jennifer R.

Quantitative genetics of dengue-2 infection and body size in laboratory and Trinidad field populations of Aedes aegypti. - 87 p.

Adviser: David W. Severson.

Thesis (Ph.D.)--University of Notre Dame, 2006.

Aedes aegypti is the primary vector of the dengue viruses (serotypes 1, 2, 3 and 4). The factors which confer susceptibility or resistance to the virus in this mosquito are largely unknown. The studies undertaken for this dissertation attempt to elucidate factors important for dengue-2 vector competence.

ISBN: 9780542809262Subjects--Topical Terms:

1018619
Biology, Entomology.

Quantitative genetics of dengue-2 infection and body size in laboratory and Trinidad field populations of Aedes aegypti.
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020 $a 9780542809262
035 $a (UnM)AAI3227775
035 $a AAI3227775
040 $a UnM $c UnM
100 1 $a Schneider, Jennifer R. $3 1288138
245 1 0 $a Quantitative genetics of dengue-2 infection and body size in laboratory and Trinidad field populations of Aedes aegypti.
300 $a 87 p.
500 $a Adviser: David W. Severson.
500 $a Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3570.
502 $a Thesis (Ph.D.)--University of Notre Dame, 2006.
520 $a Aedes aegypti is the primary vector of the dengue viruses (serotypes 1, 2, 3 and 4). The factors which confer susceptibility or resistance to the virus in this mosquito are largely unknown. The studies undertaken for this dissertation attempt to elucidate factors important for dengue-2 vector competence.
520 $a Ten Ae. aegypti populations were surveyed for dengue-2 susceptibility and body size. The preliminary findings from this experiment revealed that large mosquitoes are more likely to have a disseminated infection than small mosquitoes. Additionally, 2 strains which had previously been selected from the strain Moyo-in-dry for Plasmodium gallinaceum susceptibility (Moyo-S) and resistance (Moyo-R) were also found to have differing susceptibilities to dengue-2 disseminated infection and significantly different mean body size.
520 $a Extensive genotyping was performed to obtain broad genome screens of the Ae. aegypti strains Moyo-S and Moyo-R. Fifty-five markers were examined of which 32 were polymorphic between strains, demonstrating significant variability between the two strains. Significant strain-specific differences in allele frequencies and unique alleles were evident, and QTL common to both P. gallinaceum and dengue susceptibility were found to regularly overlap throughout the genome. The data, therefore, clearly support previous studies demonstrating that both P. gallinaceum and dengue-2 susceptibility are complex traits, genetically, with many genes influencing each of the phenotypes.
520 $a Studies of heritability of body size were performed to determine how the narrow-sense heritability compared across a range of Ae. aegypti populations when reared under the same environmental conditions. Individuals most closely derived from the field had very high heritability estimates, revealing either significant genetic variation or novel genes. Individuals from the lab had lower heritability estimates, signifying either previous selection or adaptation to the laboratory rearing environment.
520 $a The results of this dissertation demonstrate the complexities of vector competence and raise additional questions for future research. Identifying and characterizing the genes affecting vector competence that are linked with the polymorphic sites identified in these studies should prove key to efforts directed toward interrupting the cycle of dengue transmission throughout the world.
590 $a School code: 0165.
650 4 $a Biology, Entomology. $3 1018619
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Parasitology. $3 1028974
690 $a 0353
690 $a 0369
690 $a 0718
710 2 0 $a University of Notre Dame. $3 807615
773 0 $t Dissertation Abstracts International $g 67-07B.
790 $a 0165
790 1 0 $a Severson, David W., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3227775