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Eye growth and differentiation in th...

Strickler, Allen Gordon.

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Eye growth and differentiation in the blind cavefish Astyanax mexicanus: A study in the evolution of development.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Eye growth and differentiation in the blind cavefish Astyanax mexicanus: A study in the evolution of development./
Author:	Strickler, Allen Gordon.
Description:	283 p.
Notes:	Adviser: William R. Jeffery.
Contained By:	Dissertation Abstracts International67-06B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222473
ISBN:	9780542733529

Eye growth and differentiation in the blind cavefish Astyanax mexicanus: A study in the evolution of development.
Strickler, Allen Gordon.

Eye growth and differentiation in the blind cavefish Astyanax mexicanus: A study in the evolution of development. - 283 p.

Adviser: William R. Jeffery.

Thesis (Ph.D.)--University of Maryland, College Park, 2006.

"Embryology is to me by far the strongest class of facts in favor of change of forms" -Charles Darwin, in a letter to Asa Gray, September 10, 1860.

ISBN: 9780542733529Subjects--Topical Terms:

1017730
Biology, Genetics.

Eye growth and differentiation in the blind cavefish Astyanax mexicanus: A study in the evolution of development.
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020 $a 9780542733529
035 $a (UnM)AAI3222473
035 $a AAI3222473
040 $a UnM $c UnM
100 1 $a Strickler, Allen Gordon. $3 1288135
245 1 0 $a Eye growth and differentiation in the blind cavefish Astyanax mexicanus: A study in the evolution of development.
300 $a 283 p.
500 $a Adviser: William R. Jeffery.
500 $a Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 2974.
502 $a Thesis (Ph.D.)--University of Maryland, College Park, 2006.
520 $a "Embryology is to me by far the strongest class of facts in favor of change of forms" -Charles Darwin, in a letter to Asa Gray, September 10, 1860.
520 $a Modern biological studies often employ a synthesis of multiple fields to accomplish a unified research goal. For instance, evolution of development (evo-devo) answers questions concerning the emergence of unique organismal phenotypes resulting from changes in evolutionary and developmental forces. I am interested in studying these forces on a microevolutionary scale. To accomplish this, I use the teleost fish Astyanax mexicanus. This species, indigenous to Mexico, is comprised of two forms: a surface stream dwelling form (surface fish) and a cave dwelling form (cavefish). Cavefish, which are the evolutionary descendent of surface fish, have evolved a number of constructive and regressive features as a result of being exposed to the subterranean environment, including loss of functional eyes and melanin pigment. Thus, Astyanax is ideal for comparative studies on a microevolutionary scale. I am interested in studying changes in eye development between surface fish and cavefish, and how this may relate to the evolution of the two forms. I initially utilized a comparative approach, using candidate gene, cell proliferation, and cell death studies. I extended these studies to include differential gene expression analyses as a means to better understand differences between surface fish and cavefish development. To further this understanding, I ultimately performed surface fish to cavefish lens transplants and surface fish lens deletions to study the effect of the lens on eye development. Finally, I integrate these data into a theory concerning eye development in Astyanax and put these developmental phenomena in the context of evolution.
590 $a School code: 0117.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0369
710 2 0 $a University of Maryland, College Park. $3 657686
773 0 $t Dissertation Abstracts International $g 67-06B.
790 $a 0117
790 1 0 $a Jeffery, William R., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222473