東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Peripheral expression of plasma gels...

Hirko, Aaron.

Linked to FindBook

Google Book

Amazon

博客來

Peripheral expression of plasma gelsolin as a treatment for Alzheimer's disease.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Peripheral expression of plasma gelsolin as a treatment for Alzheimer's disease./
Author:	Hirko, Aaron.
Description:	136 p.
Notes:	Adviser: Jeffrey Hughes.
Contained By:	Dissertation Abstracts International67-07B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3228730
ISBN:	9780542806308

Peripheral expression of plasma gelsolin as a treatment for Alzheimer's disease.
Hirko, Aaron.

Peripheral expression of plasma gelsolin as a treatment for Alzheimer's disease. - 136 p.

Adviser: Jeffrey Hughes.

Thesis (Ph.D.)--University of Florida, 2006.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting memory, thinking, behavior, and emotion. It is characterized by a progressive accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles. Evidence suggests that the deposition of amyloid triggers a cascade that ultimately leads to Alzheimer's pathology, making amyloid a promising target for the treatment of AD. Amyloid plaques are composed mainly of the 4.5 kD peptide fragment amyloid beta (Abeta). One strategy targeting Abeta is to deliver an Abeta binding agent outside the brain, creating a peripheral sink that causes efflux of Abeta across the blood-brain barrier.

ISBN: 9780542806308Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Peripheral expression of plasma gelsolin as a treatment for Alzheimer's disease.
LDR:02613nam 2200301 a 45 001 964056
005 20110901
008 110901s2006 eng d
020 $a 9780542806308
035 $a (UMI)AAI3228730
035 $a AAI3228730
040 $a UMI $c UMI
100 1 $a Hirko, Aaron. $3 1287127
245 1 0 $a Peripheral expression of plasma gelsolin as a treatment for Alzheimer's disease.
300 $a 136 p.
500 $a Adviser: Jeffrey Hughes.
500 $a Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3727.
502 $a Thesis (Ph.D.)--University of Florida, 2006.
520 $a Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting memory, thinking, behavior, and emotion. It is characterized by a progressive accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles. Evidence suggests that the deposition of amyloid triggers a cascade that ultimately leads to Alzheimer's pathology, making amyloid a promising target for the treatment of AD. Amyloid plaques are composed mainly of the 4.5 kD peptide fragment amyloid beta (Abeta). One strategy targeting Abeta is to deliver an Abeta binding agent outside the brain, creating a peripheral sink that causes efflux of Abeta across the blood-brain barrier.
520 $a One such agent is the 89 kD protein plasma gelsolin. However, administering such a large compound poses formidable formulations challenges, and proteins generally have poor pharmacokinetic properties. Taking a gene-therapy approach by delivering a DNA vector coding for plasma gelsolin offers an alternative to repeated injections of protein.
520 $a We developed a plasmid vector for human plasma gelsolin. We determined that plasma gelsolin may have enzymatic-like functions toward Abeta, shifting the equilibrium from fibrillization and deposition to solubilization and elimination. We obtained expression of our plasmid vector for plasma gelsolin in the periphery of 2 different mouse models of Alzheimer's, and showed that it results in a significant reduction in the amount of Abeta in the brain. We also showed that this reduction of Abeta in the brain may occur along with an increase in microglia activity. These results show the validity of using plasma gelsolin as a peripheral gene therapy of Alzheimer's disease.
590 $a School code: 0070.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0419
690 $a 0572
710 2 0 $a University of Florida. $3 718949
773 0 $t Dissertation Abstracts International $g 67-07B.
790 $a 0070
790 1 0 $a Hughes, Jeffrey, $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3228730