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RNA editing of the human K(v)1.1 pot...

Bhalla, Tarun.

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RNA editing of the human K(v)1.1 potassium channel.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	RNA editing of the human K(v)1.1 potassium channel./
Author:	Bhalla, Tarun.
Description:	138 p.
Notes:	Adviser: Robert A. Reenan.
Contained By:	Dissertation Abstracts International67-06B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3221528
ISBN:	9780542742521

RNA editing of the human K(v)1.1 potassium channel.
Bhalla, Tarun.

RNA editing of the human K(v)1.1 potassium channel. - 138 p.

Adviser: Robert A. Reenan.

Thesis (Ph.D.)--University of Connecticut, 2006.

Potassium (K+) channels in the nervous system serve many roles: maintaining the resting membrane potential, regulating cell volume, and tuning the firing properties of a given neuron. The delayed rectifier function of K+ channels allows nerve cells to efficiently repolarize following an action potential. Mutations in K+ channels have been reported to cause many neurological diseases. Episodic Ataxia/Myokymia Syndrome Type 1 (EA1) is the only human ataxia known to be caused by dysfunction of a K+ channel EA1 is an inherited autosomal dominant human neurological disorder that affects both peripheral and central nerve functions. In addition, patients affected by EA1 have an estimated 10-fold increased risk to develop epilepsy. The gene responsible for EA1 has been identified as KCNA1, which encodes the Shaker-like voltage gated potassium channel Kv1.1 in mammals. Most mutations that underlie EA1 have been shown to alter the biophysical properties of Kv1.1 channels.

ISBN: 9780542742521Subjects--Topical Terms:

1017730
Biology, Genetics.

RNA editing of the human K(v)1.1 potassium channel.
LDR:02579nam 2200301 a 45 001 964048
005 20110901
008 110901s2006 eng d
020 $a 9780542742521
035 $a (UMI)AAI3221528
035 $a AAI3221528
040 $a UMI $c UMI
100 1 $a Bhalla, Tarun. $3 1287120
245 1 0 $a RNA editing of the human K(v)1.1 potassium channel.
300 $a 138 p.
500 $a Adviser: Robert A. Reenan.
500 $a Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 2940.
502 $a Thesis (Ph.D.)--University of Connecticut, 2006.
520 $a Potassium (K+) channels in the nervous system serve many roles: maintaining the resting membrane potential, regulating cell volume, and tuning the firing properties of a given neuron. The delayed rectifier function of K+ channels allows nerve cells to efficiently repolarize following an action potential. Mutations in K+ channels have been reported to cause many neurological diseases. Episodic Ataxia/Myokymia Syndrome Type 1 (EA1) is the only human ataxia known to be caused by dysfunction of a K+ channel EA1 is an inherited autosomal dominant human neurological disorder that affects both peripheral and central nerve functions. In addition, patients affected by EA1 have an estimated 10-fold increased risk to develop epilepsy. The gene responsible for EA1 has been identified as KCNA1, which encodes the Shaker-like voltage gated potassium channel Kv1.1 in mammals. Most mutations that underlie EA1 have been shown to alter the biophysical properties of Kv1.1 channels.
520 $a Adenosine-to-inosine (A-to-I) pre-mRNA editing is a post-transcriptional chemical modification, which generates an RNA transcript with a nucleotide sequence different from its gene. We have discovered that the KCNA1 transcript is a target of RNA editing in its coding sequence at a very highly conserved amino-acid position. We have also observed that the spatial regulation of RNA editing for Kv1.1 is evolutionarily conserved between rodents and humans. RNA editing at this site causes an isoleucine to valine change at a residue position known to be important for channel function. The studies below aim to understand the functional consequences of RNA editing of Kv1.1 in the mammalian nervous system.
590 $a School code: 0056.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Neuroscience. $3 1017680
690 $a 0307
690 $a 0317
690 $a 0369
710 2 0 $a University of Connecticut. $3 1017435
773 0 $t Dissertation Abstracts International $g 67-06B.
790 $a 0056
790 1 0 $a Reenan, Robert A., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3221528