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Natural products studies of the mari...

Han, Bingnan.

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Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula./
Author:	Han, Bingnan.
Description:	155 p.
Notes:	Adviser: William H. Gerwick.
Contained By:	Dissertation Abstracts International66-10B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3190900
ISBN:	9780542333750

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula.
Han, Bingnan.

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula. - 155 p.

Adviser: William H. Gerwick.

Thesis (Ph.D.)--Oregon State University, 2006.

This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively.

ISBN: 9780542333750Subjects--Topical Terms:

1017734
Biology, Microbiology.

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula.
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020 $a 9780542333750
035 $a (UMI)AAI3190900
035 $a AAI3190900
040 $a UMI $c UMI
100 1 $a Han, Bingnan. $3 1287102
245 1 0 $a Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula.
300 $a 155 p.
500 $a Adviser: William H. Gerwick.
500 $a Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5343.
502 $a Thesis (Ph.D.)--Oregon State University, 2006.
520 $a This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively.
520 $a Preliminary bioassays of the crude organic extract of the marine cyanobacterium Lyngbya semiplena collected from Papua New Guinea in 1999, showed good activity in the brine shrimp toxicity model at 10 ppm. Guided by this assay, seven new anandamide-like fatty acid amides, semiplenamides A to G, together with four cyclic depsipeptides, wewakpeptins A to D, were identified. Due to the structural resemblance of the novel ethanolamide derivatives (semiplenamide A-G) with anandamide, (N-arachidonoyi-ethanolamide), an endogenous agonist of cannabinoid receptors compounds, semiplenamide A-G were tested on the well characterized proteins of the endocannabinoid system: (1) the "central" cannabinoid CB1 receptors; (2) the anandamide membrane transporter (AMT), which is responsible for anandamide cellular uptake; and (3) the fatty acid amide hydrolase (FAAH), which catalyses anandamide hydrolysis. Three showed modest potency in displacing radiolabeled anandamide from the cannabinoid receptor (CB1), and one was a modest inhibitor of the anandamide membrane transporter (AMT). The wewakpeptins were tested for cytotoxicity to NCI-H460 human lung tumor and neuro-2a mouse neuroblastoma cells. Intriguingly, wewakpeptin A and B were approximately 10-fold more toxic than C and D to these cell lines.
520 $a Lyngbya majuscula has been recognized as a chemically and biologically rich strain. Five new lyngbyabellin analogs, lyngbyabellins E-I, along with the known compound dolabellin, originally isolated from sea hare Dolabella auricularia, were identified from a 2002 Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula . The lyngbyabellins were tested for cytotoxicity to NCI-H460 human lung tumor and neuro-2a mouse neuroblastoma cells and had LC50 values between 0.2 and 4.8 muM. Intriguingly, lyngbyabellin E and H appeared to be more active against the H460 cell line with LC50 values of 0.4 muM and 0.2 muM, respectively, compared to LC50 values of 1.2 and 1.4 muM in the neuro-2a cell line. Lynbyabellin I was the most toxic to neuro-2a cells (LC50 0.7 muM), whereas lyngbyabellin G, was the least cytotoxic of all compounds to either cell line. On the basis of this limited screening, it appears that lung tumor cell toxicity is enhanced in the cyclic representatives, and overall potency is increased in those containing an elaborated side chain. (Abstract shortened by UMI.)
590 $a School code: 0172.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Oceanography. $3 783691
650 4 $a Chemistry, Pharmaceutical. $3 550957
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0410
690 $a 0416
690 $a 0491
690 $a 0572
710 2 0 $a Oregon State University. $3 625720
773 0 $t Dissertation Abstracts International $g 66-10B.
790 $a 0172
790 1 0 $a Gerwick, William H., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3190900