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Natural antioxidants: Their electroc...

Corredor-Sanchez, Piedad Stella.

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Natural antioxidants: Their electrochemistry and determination in plant material and biological fluids.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Natural antioxidants: Their electrochemistry and determination in plant material and biological fluids./
Author:	Corredor-Sanchez, Piedad Stella.
Description:	269 p.
Notes:	Adviser: Peter T. Kissinger.
Contained By:	Dissertation Abstracts International68-10B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3287195
ISBN:	9780549302520

Natural antioxidants: Their electrochemistry and determination in plant material and biological fluids.
Corredor-Sanchez, Piedad Stella.

Natural antioxidants: Their electrochemistry and determination in plant material and biological fluids. - 269 p.

Adviser: Peter T. Kissinger.

Thesis (Ph.D.)--Purdue University, 2007.

Natural antioxidants are reported to have high potential as health boosters. Consumption of such compounds has dramatically increased in recent years although there is very little to substantiate their benefit. Interactions of drugs with dietary supplements, nutraceuticals or botanicals, as they are variously called, are only beginning to be understood. In order to better define the role of antioxidants it is desirable to have improved analytical methods for plant derived materials as they are processed, stored and consumed. The electrochemistry of representative antioxidants including: chlorogenic acid, caffeic acid and curcumin is studied in this work. Validated methods for the determination of caffeic acid and chlorogenic acid in coffee were developed to follow the content of these compounds during the roasting process. Other methods were designed to follow the dynamics of these compounds in fully functional mammalian biological systems, particularly in rodents. Validated LCUVEC and LCMS methods for the determination of curcuminoids, caffeic and chlorogenic acids both in food and in biological fluids permits study of pharmacokinetics. Determination of some primary and secondary metabolites was also achieved. Higher quality pharmacokinetics data was obtained by using an automated pharmacology unit (Culex), thus reducing animal stress during the study.

ISBN: 9780549302520Subjects--Topical Terms:

586156
Chemistry, Analytical.

Natural antioxidants: Their electrochemistry and determination in plant material and biological fluids.
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020 $a 9780549302520
035 $a (UMI)AAI3287195
035 $a AAI3287195
040 $a UMI $c UMI
100 1 $a Corredor-Sanchez, Piedad Stella. $3 1285843
245 1 0 $a Natural antioxidants: Their electrochemistry and determination in plant material and biological fluids.
300 $a 269 p.
500 $a Adviser: Peter T. Kissinger.
500 $a Source: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6632.
502 $a Thesis (Ph.D.)--Purdue University, 2007.
520 $a Natural antioxidants are reported to have high potential as health boosters. Consumption of such compounds has dramatically increased in recent years although there is very little to substantiate their benefit. Interactions of drugs with dietary supplements, nutraceuticals or botanicals, as they are variously called, are only beginning to be understood. In order to better define the role of antioxidants it is desirable to have improved analytical methods for plant derived materials as they are processed, stored and consumed. The electrochemistry of representative antioxidants including: chlorogenic acid, caffeic acid and curcumin is studied in this work. Validated methods for the determination of caffeic acid and chlorogenic acid in coffee were developed to follow the content of these compounds during the roasting process. Other methods were designed to follow the dynamics of these compounds in fully functional mammalian biological systems, particularly in rodents. Validated LCUVEC and LCMS methods for the determination of curcuminoids, caffeic and chlorogenic acids both in food and in biological fluids permits study of pharmacokinetics. Determination of some primary and secondary metabolites was also achieved. Higher quality pharmacokinetics data was obtained by using an automated pharmacology unit (Culex), thus reducing animal stress during the study.
590 $a School code: 0183.
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0486
710 2 $a Purdue University. $b Chemistry. $3 1019176
773 0 $t Dissertation Abstracts International $g 68-10B.
790 $a 0183
790 1 0 $a Kissinger, Peter T., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3287195