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The exploration of gas-phase stereos...

Young-Gqamana, Brandy Leah.

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The exploration of gas-phase stereospecific interactions in the mass spectrometer.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The exploration of gas-phase stereospecific interactions in the mass spectrometer./
作者:	Young-Gqamana, Brandy Leah.
面頁冊數:	136 p.
附註:	Adviser: R. Graham Cooks.
Contained By:	Dissertation Abstracts International68-08B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3278695
ISBN:	9780549167075

The exploration of gas-phase stereospecific interactions in the mass spectrometer.
Young-Gqamana, Brandy Leah.

The exploration of gas-phase stereospecific interactions in the mass spectrometer. - 136 p.

Adviser: R. Graham Cooks.

Thesis (Ph.D.)--Purdue University, 2007.

Gas-phase stereospecific interactions were investigated using tandem mass spectrometry and the kinetic method, a sensitive linear free energy method of treating mass spectrometric results that are converted into thermochemical data. Enantiospecific interactions were created through the formation of a metal complex chelated with a chiral analyte and two chiral references to form a trimeric cluster ion. The chiral purity of the trimeric cluster ion was probed as a result of dissociation by collisional activation and the results obtained were treated by the kinetic method. Chiral and isomeric recognition were achieved for various systems: drugs, peptides, and amino acids.

ISBN: 9780549167075Subjects--Topical Terms:

586156
Chemistry, Analytical.

The exploration of gas-phase stereospecific interactions in the mass spectrometer.
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245 1 4 $a The exploration of gas-phase stereospecific interactions in the mass spectrometer.
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502 $a Thesis (Ph.D.)--Purdue University, 2007.
520 $a Gas-phase stereospecific interactions were investigated using tandem mass spectrometry and the kinetic method, a sensitive linear free energy method of treating mass spectrometric results that are converted into thermochemical data. Enantiospecific interactions were created through the formation of a metal complex chelated with a chiral analyte and two chiral references to form a trimeric cluster ion. The chiral purity of the trimeric cluster ion was probed as a result of dissociation by collisional activation and the results obtained were treated by the kinetic method. Chiral and isomeric recognition were achieved for various systems: drugs, peptides, and amino acids.
520 $a Enantioselectivity was improved with the addition of a fixed non-dissociating ligand in the trimeric cluster ion of various positional tetrapeptide complexes. The enantioselectivity determined by the single ratio version of the kinetic method, was compared to that determined by the fixed-ligand version of the kinetic method. The changes in enantioselectivity were judged against changes in the transition metal cations and positional tetrapeptides. Quantitative improvements in MS based chiral methods were also shown, where two new methodologies, the vernier method and the standard addition method, were developed to (1) determine the chirality of enantiomericlly pure samples more accurately and (2) to get quantitative data from a non-linear calibration plot, respectively. In a different study, comparisons between two instrumental techniques, MS and chromatography, as well as two ionization techniques, DESI and ESI, for the chiral purity determination of pharmaceutical drug candidates were made. The evaluation of method validation parameters in addition to DESI ionization demonstrated the promise of MS as a high-throughput technique for pharmaceutical applications.
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