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Angle-resolved optical coherence tom...

Desjardins, Adrien Emmanuel.

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Angle-resolved optical coherence tomography.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Angle-resolved optical coherence tomography./
Author:	Desjardins, Adrien Emmanuel.
Description:	149 p.
Notes:	Advisers: Brett E. Bouma; Guillermo J. Tearney.
Contained By:	Dissertation Abstracts International68-05B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3265165
ISBN:	9780549024705

Angle-resolved optical coherence tomography.
Desjardins, Adrien Emmanuel.

Angle-resolved optical coherence tomography. - 149 p.

Advisers: Brett E. Bouma; Guillermo J. Tearney.

Thesis (Ph.D.)--Harvard University, 2007.

Optical coherence tomography (OCT) has emerged as a powerful tool for probing the microstructure of biological tissue non-invasively at high-speed. OCT measures depth-resolved reflectance of infrared light, generating cross-sectional images non-invasively with micron-scale resolution. As with other imaging modalities that employ coherent detection, OCT images are confounded by speckle noise. Speckle imposes a grainy texture on images that reduces the signal-to-noise ratio to near unity values. As a result, it conceals subtle differences in scattering properties known to be crucial for differentiating normal from diseased tissue states. In this thesis, we developed a novel OCT modality called "Angle-Resolved OCT" in which depth scans (A-lines) are obtained simultaneously from a broad range of backscattering angles. We demonstrated that high levels of speckle reduction can be achieved by averaging the magnitudes of A-lines corresponding to the same transverse locations. With both experimental and analytic approaches, we demonstrated that this averaging method does not lead to a substantial loss in spatial resolution. We developed two different imaging systems for performing Angle-Resolved OCT. With the first system, angular data was acquired simultaneously; with the second, it was acquired sequentially. The first system had superior speckle-reduction capabilities but image quality degraded significantly with small sample movements. The second system allowed for in vivo imaging, as demonstrated with Resolved OCT systems, the speckle-reduced images showed hitherto unprecedented delineation of tissue microstructure.

ISBN: 9780549024705Subjects--Topical Terms:

1017681
Biophysics, Medical.

Angle-resolved optical coherence tomography.
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020 $a 9780549024705
035 $a (UMI)AAI3265165
035 $a AAI3265165
040 $a UMI $c UMI
100 1 $a Desjardins, Adrien Emmanuel. $3 1285753
245 1 0 $a Angle-resolved optical coherence tomography.
300 $a 149 p.
500 $a Advisers: Brett E. Bouma; Guillermo J. Tearney.
500 $a Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 2893.
502 $a Thesis (Ph.D.)--Harvard University, 2007.
520 $a Optical coherence tomography (OCT) has emerged as a powerful tool for probing the microstructure of biological tissue non-invasively at high-speed. OCT measures depth-resolved reflectance of infrared light, generating cross-sectional images non-invasively with micron-scale resolution. As with other imaging modalities that employ coherent detection, OCT images are confounded by speckle noise. Speckle imposes a grainy texture on images that reduces the signal-to-noise ratio to near unity values. As a result, it conceals subtle differences in scattering properties known to be crucial for differentiating normal from diseased tissue states. In this thesis, we developed a novel OCT modality called "Angle-Resolved OCT" in which depth scans (A-lines) are obtained simultaneously from a broad range of backscattering angles. We demonstrated that high levels of speckle reduction can be achieved by averaging the magnitudes of A-lines corresponding to the same transverse locations. With both experimental and analytic approaches, we demonstrated that this averaging method does not lead to a substantial loss in spatial resolution. We developed two different imaging systems for performing Angle-Resolved OCT. With the first system, angular data was acquired simultaneously; with the second, it was acquired sequentially. The first system had superior speckle-reduction capabilities but image quality degraded significantly with small sample movements. The second system allowed for in vivo imaging, as demonstrated with Resolved OCT systems, the speckle-reduced images showed hitherto unprecedented delineation of tissue microstructure.
590 $a School code: 0084.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Physics, Optics. $3 1018756
690 $a 0752
690 $a 0760
710 2 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 68-05B.
790 $a 0084
790 1 0 $a Bouma, Brett E., $e advisor
790 1 0 $a Tearney, Guillermo J., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3265165