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T cells, pregnancy and multiple scle...

Langer-Gould, Annette.

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T cells, pregnancy and multiple sclerosis.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	T cells, pregnancy and multiple sclerosis./
Author:	Langer-Gould, Annette.
Description:	83 p.
Notes:	Adviser: Lorene M. Nelson.
Contained By:	Dissertation Abstracts International68-02B.
Subject:	Health Sciences, Epidemiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253506

T cells, pregnancy and multiple sclerosis.
Langer-Gould, Annette.

T cells, pregnancy and multiple sclerosis. - 83 p.

Adviser: Lorene M. Nelson.

Thesis (Ph.D.)--Stanford University, 2007.

Background. A large proportion of women with MS experience disease amelioration during pregnancy and relapses in the postpartum period. The migration of activated T cells from periphery into the CNS is a critical step in MS relapses.Subjects--Topical Terms:

1019544
Health Sciences, Epidemiology.

T cells, pregnancy and multiple sclerosis.
LDR:03246nam 2200325 a 45 001 962688
005 20110830
008 110831s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI3253506
035 $a AAI3253506
040 $a UMI $c UMI
100 1 $a Langer-Gould, Annette. $3 1285748
245 1 0 $a T cells, pregnancy and multiple sclerosis.
300 $a 83 p.
500 $a Adviser: Lorene M. Nelson.
500 $a Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 0870.
502 $a Thesis (Ph.D.)--Stanford University, 2007.
520 $a Background. A large proportion of women with MS experience disease amelioration during pregnancy and relapses in the postpartum period. The migration of activated T cells from periphery into the CNS is a critical step in MS relapses.
520 $a Objective. To describe the changes in fine T-cell subsets that occur during pregnancy and the postpartum period in women with multiple sclerosis (MS) and to determine their correlation with disease course.
520 $a Methods. We enrolled 17 pregnant women with MS and 12 matched, healthy pregnant women. PBMCs were obtained during each trimester and 2,4,6,9 and 12 months postpartum and viably frozen. Following stimulation with anti-CD28 and anti-CD3, fine T-cell subsets were identified by expression of various surface antigens and intracellular cytokines using the FACSAria cell-sorter. The data were analyzed using longitudinal data methods aimed at identifying patterns over time while accounting for inter- and intra-individual variation.
520 $a Results. Thirteen women with MS (76%) had relapses during the study period. In these women, CD4+CD45RA-IFNgamma lymphocytes peaked and then declined three to five months prior to the onset of relapse (p=0.025), which differed significantly from non-relapsing women with MS and healthy pregnant women during the corresponding time period. CD4+TNF+ cells significantly increased between 100 and 10 days prior to the onset of relapse symptoms (p=0.036). The four women with MS who did not relapse had a higher proportion of CD8+CD45RA+IL2+ and CD4+CD45RA-IL2+ cells compared with women with MS who relapsed and healthy women throughout the study period (p=0.026 and 0.047, respectively).
520 $a Conclusions. Our findings suggest that CD4+IFNgamma-producing cells may transit to the CNS as early as three to five months prior to the onset of relapse symptoms. Our findings also suggest that IL2-producing CD4 memory and CD8-naive cells may be adaptive suppressor cells associated with long periods of clinical remission. This study casts doubt on the hypothesis that pregnancy-induced changes in cytokine-producing T-cell subsets explain why women with MS experience fewer relapses during pregnancy and more relapses in the postpartum period. Our data suggest that alternative mechanisms such as induction of suppressor cell populations and inhibition of transmigration should be explored.
590 $a School code: 0212.
650 4 $a Health Sciences, Epidemiology. $3 1019544
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Health Sciences, Obstetrics and Gynecology. $3 1020690
690 $a 0380
690 $a 0766
690 $a 0982
710 2 $a Stanford University. $3 754827
773 0 $t Dissertation Abstracts International $g 68-02B.
790 $a 0212
790 1 0 $a Nelson, Lorene M., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253506