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Noninvasive assessment of cardiovasc...

Lin, Zheng.

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Noninvasive assessment of cardiovascular autonomic control in pediatric sleep disordered breathing.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Noninvasive assessment of cardiovascular autonomic control in pediatric sleep disordered breathing./
作者:	Lin, Zheng.
面頁冊數:	202 p.
附註:	Adviser: Michael C. K. Khoo.
Contained By:	Dissertation Abstracts International67-10B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3237152
ISBN:	9780542912016

Noninvasive assessment of cardiovascular autonomic control in pediatric sleep disordered breathing.
Lin, Zheng.

Noninvasive assessment of cardiovascular autonomic control in pediatric sleep disordered breathing. - 202 p.

Adviser: Michael C. K. Khoo.

Thesis (Ph.D.)--University of Southern California, 2006.

Sleep Disordered breathing (SDB) describes a group of disorders characterized by abnormalities in respiratory pattern or ventilation during sleep. Obstructive sleep apnea syndrome (OSAS) is a classic example of SDB that is elicited by increased upper airway resistance along with diminished or insufficient compensatory mechanisms developing during sleep. Congenital Central Hypoventilation Syndrome (CCHS) is another extreme example of SDB characterized by alveolar hypoventilation, resulting in progressive hypercapnia and hypoxemia while asleep.

ISBN: 9780542912016Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Noninvasive assessment of cardiovascular autonomic control in pediatric sleep disordered breathing.
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245 1 0 $a Noninvasive assessment of cardiovascular autonomic control in pediatric sleep disordered breathing.
300 $a 202 p.
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502 $a Thesis (Ph.D.)--University of Southern California, 2006.
520 $a Sleep Disordered breathing (SDB) describes a group of disorders characterized by abnormalities in respiratory pattern or ventilation during sleep. Obstructive sleep apnea syndrome (OSAS) is a classic example of SDB that is elicited by increased upper airway resistance along with diminished or insufficient compensatory mechanisms developing during sleep. Congenital Central Hypoventilation Syndrome (CCHS) is another extreme example of SDB characterized by alveolar hypoventilation, resulting in progressive hypercapnia and hypoxemia while asleep.
520 $a The goal of this study was to quantify autonomic system dysfunction, as manifested by cardiovascular and respiratory response abnormalities, in pediatric OSAS and CCHS. During wakefulness, we continuously measured the ECG, arterial blood pressure (ABP), airflow, bio-impedance cardiography, end-tidal CO2 partial pressure (PETCO2), and arterial oxygen saturation (SatO2) in each subject. These measurements were made during spontaneous breathing in supine, sitting and standing postures, and also when each subject tracked his/her prior spontaneous breathing pattern while supine. We also performed the cold face test, hyperoxic hypercapnic rebreathing and the isocapnic hypoxic rebreathing challenges. Using spectral analysis and close-loop modeling techniques, we sought to computationally delineate the physiological mechanisms that mediate these abnormalities, as well as to determine whether the site of malfunction is in the central sympathetic, peripheral sympathetic or parasympathetic branches of the autonomic nervous system, and the extent to which these abnormalities are related to peripheral or central chemoreflex abnormalities.
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