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The role of keratinocyte growth fact...

Min, Dullei.

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The role of keratinocyte growth factor in thymopoiesis.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of keratinocyte growth factor in thymopoiesis./
Author:	Min, Dullei.
Description:	111 p.
Notes:	Adviser: Kenneth I. Weinberg.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3180401
ISBN:	9780542204920

The role of keratinocyte growth factor in thymopoiesis.
Min, Dullei.

The role of keratinocyte growth factor in thymopoiesis. - 111 p.

Adviser: Kenneth I. Weinberg.

Thesis (Ph.D.)--University of Southern California, 2005.

Decreased thymopoietic capacity contributes to the severe and clinically significant immune deficiency seen after irradiation, chemotherapy hematopoietic stem cell transplantation (HSCT). The ability of adults to reconstitute the T cell compartment after damage is interfered by aging. Thymic insufficiency is associated with impaired intrathymic production of IL-7 by thymic epithelial cells (TEC), possibly the loss of the IL-7-producing TEC, which can be partially treated by 1L-7 administration. It has been known that administration of keratinocyte growth factor (KGF, or Fgf7), an epithelial cell-specific growth factor, protects mucosal, cutaneous, and pulmonary epithelial cells from cytotoxic therapy-induced damage. Thus, we hypothesized that KGF treatment would improve thymic function by protecting TEC from damage or inducing TEC proliferation. A single 3-day course of KGF treatment improved thymopoiesis hampered by pre-HSCT conditioning, GVDH and aging, enhanced thymopoiesis by KGF was maintained for at least 2 months in each model. KGF increased numbers of TEC and intrathymic IL-7 production, and the observed effect of KGF required an intact IL7 signaling pathway. KGF treatment caused increased numbers of naive CD4+ T cells and total mature T cells, indicating that the increased T cell numbers resulted from enhanced thymopoiesis rather than only peripheral expansion of memory T cells. KGF treatment also enhanced T-cell dependent antibody production in response to vaccination. The ability of KGF to increase thymopoiesis and immune responsiveness suggests that TEC damage is pathophysiologically important in thymic insufficiency, and KGF may be therapeutically useful in maintenance of thymopoiesis in HSCT recipients or aged individuals.

ISBN: 9780542204920Subjects--Topical Terms:

1017686
Biology, Cell.

The role of keratinocyte growth factor in thymopoiesis.
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005 20110704
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035 $a (UMI)AAI3180401
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100 1 $a Min, Dullei. $3 1281913
245 1 4 $a The role of keratinocyte growth factor in thymopoiesis.
300 $a 111 p.
500 $a Adviser: Kenneth I. Weinberg.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3045.
502 $a Thesis (Ph.D.)--University of Southern California, 2005.
520 $a Decreased thymopoietic capacity contributes to the severe and clinically significant immune deficiency seen after irradiation, chemotherapy hematopoietic stem cell transplantation (HSCT). The ability of adults to reconstitute the T cell compartment after damage is interfered by aging. Thymic insufficiency is associated with impaired intrathymic production of IL-7 by thymic epithelial cells (TEC), possibly the loss of the IL-7-producing TEC, which can be partially treated by 1L-7 administration. It has been known that administration of keratinocyte growth factor (KGF, or Fgf7), an epithelial cell-specific growth factor, protects mucosal, cutaneous, and pulmonary epithelial cells from cytotoxic therapy-induced damage. Thus, we hypothesized that KGF treatment would improve thymic function by protecting TEC from damage or inducing TEC proliferation. A single 3-day course of KGF treatment improved thymopoiesis hampered by pre-HSCT conditioning, GVDH and aging, enhanced thymopoiesis by KGF was maintained for at least 2 months in each model. KGF increased numbers of TEC and intrathymic IL-7 production, and the observed effect of KGF required an intact IL7 signaling pathway. KGF treatment caused increased numbers of naive CD4+ T cells and total mature T cells, indicating that the increased T cell numbers resulted from enhanced thymopoiesis rather than only peripheral expansion of memory T cells. KGF treatment also enhanced T-cell dependent antibody production in response to vaccination. The ability of KGF to increase thymopoiesis and immune responsiveness suggests that TEC damage is pathophysiologically important in thymic insufficiency, and KGF may be therapeutically useful in maintenance of thymopoiesis in HSCT recipients or aged individuals.
590 $a School code: 0208.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Dentistry. $3 1019378
650 4 $a Health Sciences, Immunology. $3 1017716
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710 2 0 $a University of Southern California. $3 700129
773 0 $t Dissertation Abstracts International $g 66-06B.
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