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Pure insulin nanoparticle agglomerat...

Bailey, Mark M.

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Pure insulin nanoparticle agglomerates for pulmonary delivery.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Pure insulin nanoparticle agglomerates for pulmonary delivery./
Author:	Bailey, Mark M.
Description:	77 p.
Notes:	Adviser: Cory J. Berkland.
Contained By:	Masters Abstracts International46-05.
Subject:	Chemistry, Pharmaceutical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1450450
ISBN:	9780549489467

Pure insulin nanoparticle agglomerates for pulmonary delivery.
Bailey, Mark M.

Pure insulin nanoparticle agglomerates for pulmonary delivery. - 77 p.

Adviser: Cory J. Berkland.

Thesis (M.S.)--University of Kansas, 2008.

Diabetes is a disease characterized by defects in insulin utilization, either through autoimmune destruction of insulin-producing cells (Type I) or insulin resistance (Type II). Treatment includes regular insulin injections, which can be painful and inconvenient, often leading to low patient compliance. To overcome this problem, novel formulations of insulin are being investigated, such as inhaled aerosols. Sufficient deposition of powder in the distal regions of the lung to maximize systemic absorption requires precise control over particle size, with particles between 1 and 5 microns in aerodynamic diameter being within the respirable range. Insulin nanoparticles were produced by titrating insulin dissolved at low pH to the pI of the native protein, and were then processed into microparticles using solvent displacement. Particle size, crystallinity, dissolution properties, stability, and powder density were characterized. This work demonstrates that pure insulin microparticles can be produced from nanosuspensions with minimal processing steps and with suitable properties for deposition in the peripheral lung.

ISBN: 9780549489467Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Pure insulin nanoparticle agglomerates for pulmonary delivery.
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020 $a 9780549489467
035 $a (UMI)AAI1450450
035 $a AAI1450450
040 $a UMI $c UMI
100 1 $a Bailey, Mark M. $3 1281078
245 1 0 $a Pure insulin nanoparticle agglomerates for pulmonary delivery.
300 $a 77 p.
500 $a Adviser: Cory J. Berkland.
500 $a Source: Masters Abstracts International, Volume: 46-05, page: 2748.
502 $a Thesis (M.S.)--University of Kansas, 2008.
520 $a Diabetes is a disease characterized by defects in insulin utilization, either through autoimmune destruction of insulin-producing cells (Type I) or insulin resistance (Type II). Treatment includes regular insulin injections, which can be painful and inconvenient, often leading to low patient compliance. To overcome this problem, novel formulations of insulin are being investigated, such as inhaled aerosols. Sufficient deposition of powder in the distal regions of the lung to maximize systemic absorption requires precise control over particle size, with particles between 1 and 5 microns in aerodynamic diameter being within the respirable range. Insulin nanoparticles were produced by titrating insulin dissolved at low pH to the pI of the native protein, and were then processed into microparticles using solvent displacement. Particle size, crystallinity, dissolution properties, stability, and powder density were characterized. This work demonstrates that pure insulin microparticles can be produced from nanosuspensions with minimal processing steps and with suitable properties for deposition in the peripheral lung.
590 $a School code: 0099.
650 4 $a Chemistry, Pharmaceutical. $3 550957
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Chemical. $3 1018531
690 $a 0491
690 $a 0541
690 $a 0542
710 2 $a University of Kansas. $b Chemical & Petroleum Engineering. $3 1023774
773 0 $t Masters Abstracts International $g 46-05.
790 $a 0099
790 1 0 $a Berkland, Cory J., $e advisor
790 1 0 $a Detamore, Michael S. $e committee member
790 1 0 $a Guzman, Javier $e committee member
791 $a M.S.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1450450