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Swine models for study and optimizat...

Kimmel, Michael William.

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Swine models for study and optimization of biventricular pacing therapies as treatments for heart failure.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Swine models for study and optimization of biventricular pacing therapies as treatments for heart failure./
Author:	Kimmel, Michael William.
Description:	242 p.
Notes:	Adviser: Paul A. Iaizzo.
Contained By:	Dissertation Abstracts International69-01B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3295691
ISBN:	9780549405153

Swine models for study and optimization of biventricular pacing therapies as treatments for heart failure.
Kimmel, Michael William.

Swine models for study and optimization of biventricular pacing therapies as treatments for heart failure. - 242 p.

Adviser: Paul A. Iaizzo.

Thesis (Ph.D.)--University of Minnesota, 2008.

As a future biomedical engineer in industry, my goal for this thesis was to develop and utilize a complete "tool set" that would allow investigation into pacing and other therapies, in particular for heart failure (HF). Acute and chronic swine studies were performed with the goal of providing translational results through use of appropriate animal models and simultaneously examining anatomical and functional parameters with direct clinical application. It is my hope that this work can help future researchers in the field ensure the most relevant and valuable data is collected during similar investigations. The end goal of such research is improved patient therapy, and by making use of appropriate animal models prior to human research, patient risk is minimized.

ISBN: 9780549405153Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Swine models for study and optimization of biventricular pacing therapies as treatments for heart failure.
LDR:03261nam 2200313 a 45 001 957674
005 20110630
008 110630s2008 ||||||||||||||||| ||eng d
020 $a 9780549405153
035 $a (UMI)AAI3295691
035 $a AAI3295691
040 $a UMI $c UMI
100 1 $a Kimmel, Michael William. $3 1281017
245 1 0 $a Swine models for study and optimization of biventricular pacing therapies as treatments for heart failure.
300 $a 242 p.
500 $a Adviser: Paul A. Iaizzo.
500 $a Source: Dissertation Abstracts International, Volume: 69-01, Section: B, page: 0466.
502 $a Thesis (Ph.D.)--University of Minnesota, 2008.
520 $a As a future biomedical engineer in industry, my goal for this thesis was to develop and utilize a complete "tool set" that would allow investigation into pacing and other therapies, in particular for heart failure (HF). Acute and chronic swine studies were performed with the goal of providing translational results through use of appropriate animal models and simultaneously examining anatomical and functional parameters with direct clinical application. It is my hope that this work can help future researchers in the field ensure the most relevant and valuable data is collected during similar investigations. The end goal of such research is improved patient therapy, and by making use of appropriate animal models prior to human research, patient risk is minimized.
520 $a The studies described herein used in situ and in vitro swine models of varying complexities, including acute infarction and high-rate pacing, to investigate several aspects of HF, including the ischemic cardiac response to lipid compounds and efficacy of numerous pacing modes as treatments. Multiple measuring methodologies were employed to examine multiple aspects of cardiac function, including: hemodynamics, sonomicrometry, endocardial electrical mapping, echocardiography, and MRI, resulting in large amounts of data.
520 $a The overall results of this thesis were that: (1) Acute and chronic swine models can be used to gain insight into human cardiac physiology, (2) Lipid compounds can attenuate ischemic cardiac performance decline, (3) Cardiac pacing elicits distinct electrical activation and mechanical performance, (4) Quantitative differences in acute cardiac function were related to pacing site.
520 $a The findings of this thesis provide a background for many clinical observations found during pacing in general, and also for HF treatment, and will help further the understanding of mechanisms for patient response to pacing therapies. While the correlation between acute and chronic cardiac performance remains an open question, results from this thesis make it clear that multimodal optimization of the acute condition is possible hemodynamically, electrically, and mechanically. As clinicians strive to preserve (or restore) normal cardiac function, it is important to fully consider these many facets of "normal function."
590 $a School code: 0130.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0433
690 $a 0541
710 2 $a University of Minnesota. $3 676231
773 0 $t Dissertation Abstracts International $g 69-01B.
790 $a 0130
790 1 0 $a Iaizzo, Paul A., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3295691