東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Surface modifications of a titanium ...

Crowder, Katherine Nicole.

Linked to FindBook

Google Book

Amazon

博客來

Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications./
Author:	Crowder, Katherine Nicole.
Description:	174 p.
Notes:	Source: Dissertation Abstracts International, Volume: 68-12, Section: B, page: 8018.
Contained By:	Dissertation Abstracts International68-12B.
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3295294
ISBN:	9780549397366

Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications.
Crowder, Katherine Nicole.

Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications. - 174 p.

Source: Dissertation Abstracts International, Volume: 68-12, Section: B, page: 8018.

Thesis (Ph.D.)--Princeton University, 2008.

Titanium and its alloys, namely Ti-6Al-4V, are ideal materials for orthopedic implants; however, it remains a challenge to promote biointegration of these implants, which is essential for its long life and function within the body. A self-assembled monolayer of phosphonates (SAMP) can serve as a platform for further derivatizations that will covalently bond cell attractive biomolecules to the titanium surface in a stable manner. Bonding a cell attachment peptide, arginine-glycine-aspartic acid (RGD), to the titanium surface using the SAMP platform has been shown to increase osteoblast adhesion, spreading, and mineralization.

ISBN: 9780549397366Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications.
LDR:02768nam 2200289 a 45 001 957672
005 20110630
008 110630s2008 ||||||||||||||||| ||eng d
020 $a 9780549397366
035 $a (UMI)AAI3295294
035 $a AAI3295294
040 $a UMI $c UMI
100 1 $a Crowder, Katherine Nicole. $3 1281015
245 1 0 $a Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications.
300 $a 174 p.
500 $a Source: Dissertation Abstracts International, Volume: 68-12, Section: B, page: 8018.
502 $a Thesis (Ph.D.)--Princeton University, 2008.
520 $a Titanium and its alloys, namely Ti-6Al-4V, are ideal materials for orthopedic implants; however, it remains a challenge to promote biointegration of these implants, which is essential for its long life and function within the body. A self-assembled monolayer of phosphonates (SAMP) can serve as a platform for further derivatizations that will covalently bond cell attractive biomolecules to the titanium surface in a stable manner. Bonding a cell attachment peptide, arginine-glycine-aspartic acid (RGD), to the titanium surface using the SAMP platform has been shown to increase osteoblast adhesion, spreading, and mineralization.
520 $a Acyclic and cyclic RGD peptides were bound via the SAMP platform to Ti-6Al-4V to study the effect of peptide conformational presentation on cell adhesion in vitro; it has been proposed that cyclic forms of the peptide have a higher affinity for cell surface receptors. It was shown that acyclic RGD induces nearly equivalent cell adhesion and spreading as does cyclic RGD; it is postulated that this is due to the surfaces having a sufficiently high density of ligands so as to saturate the cell surface receptors.
520 $a The SAMP interface on Ti-6Al-4V was compared in an 8 week in vivo trial in a rat model to a reported thiolate interface on gold-coated titanium, both involving RGDC bound to the surface. The SAMP/RGD system had significantly greater new bone area at 2 weeks and new bone-to-implant contact at 8 weeks compared to the Au/RGD system.
520 $a A second, 16 week in vivo trial in rabbits compared the osteointegration of SAMP/RGD, phosphonate-terminated SAMP, and hydroxyapatite-coated quasi-porous implants. As evaluated by a pull-out test, the two SAMP coatings significantly increased the mechanical fixation of the implants. Bony ingrowth into the porous structures of the implants was promoted on the SAMP surfaces versus the hydroxyapatite coating.
590 $a School code: 0181.
650 4 $a Chemistry, Inorganic. $3 517253
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0488
690 $a 0541
710 2 $a Princeton University. $3 645579
773 0 $t Dissertation Abstracts International $g 68-12B.
790 $a 0181
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3295294