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Relating lung structure and function...

Tzeng, Yang-Sheng.

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Relating lung structure and function in asthma using hyperpolarized helium-3 MRI.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Relating lung structure and function in asthma using hyperpolarized helium-3 MRI./
Author:	Tzeng, Yang-Sheng.
Description:	182 p.
Notes:	Adviser: Kenneth R. Lutchen.
Contained By:	Dissertation Abstracts International68-08B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3279974
ISBN:	9780549212492

Relating lung structure and function in asthma using hyperpolarized helium-3 MRI.
Tzeng, Yang-Sheng.

Relating lung structure and function in asthma using hyperpolarized helium-3 MRI. - 182 p.

Adviser: Kenneth R. Lutchen.

Thesis (Ph.D.)--Boston University, 2008.

New quantitative approaches for interrogating hyperpolarized (HP) 3He MR images were developed to relate airway structure to airway hyperresponsiveness and ventilation function in healthy and asthmatic human lungs. One major effort was to establish if HP 3He MRI could quantify airway geometry pre- and post-constriction. The other major effort was to quantify how asthmatics and healthy subjects differ in ventilation distribution after imposition of bronchoconstriction and deep inspirations.

ISBN: 9780549212492Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Relating lung structure and function in asthma using hyperpolarized helium-3 MRI.
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020 $a 9780549212492
035 $a (UMI)AAI3279974
035 $a AAI3279974
040 $a UMI $c UMI
100 1 $a Tzeng, Yang-Sheng. $3 1280976
245 1 0 $a Relating lung structure and function in asthma using hyperpolarized helium-3 MRI.
300 $a 182 p.
500 $a Adviser: Kenneth R. Lutchen.
500 $a Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5396.
502 $a Thesis (Ph.D.)--Boston University, 2008.
520 $a New quantitative approaches for interrogating hyperpolarized (HP) 3He MR images were developed to relate airway structure to airway hyperresponsiveness and ventilation function in healthy and asthmatic human lungs. One major effort was to establish if HP 3He MRI could quantify airway geometry pre- and post-constriction. The other major effort was to quantify how asthmatics and healthy subjects differ in ventilation distribution after imposition of bronchoconstriction and deep inspirations.
520 $a For the first effort, a model-based algorithm was developed for measuring the diameter of tubular structures from their pixel intensity profile in the HP 3He MR images. The approach was validated on a phantom consisting of plastic tubes of different diameters connected in series, first by proton MRI and filling the phantom with gadolinium-doped water, and then by flowing HP 3He through the tubes. Limited success was also obtained with an anthropomorphic airway tree phantom. This approach was then used to evaluate airway constriction in methacholine (MCh)-challenged subjects. The airways' cross-sectional geometries were also measured using multi-detector computed tomography (MDCT), the current gold standard. There was unsatisfactory concordance between the airway changes as assessed by Hp 3He MRI and those using MDCT.
520 $a In the second effort, Hp 3He MR static ventilation images were acquired at baseline, and in response to bronchial challenge and DI's. After coregistering the preMCh, postMCh, and postDI image sets, the ventilated voxel fractions were calculated through determining the pixel intensity-to-volume factor for each image set, and the ventilation heterogeneity mapped by computing the local coefficient-of-variation. Emergence of ventilation defects and elevation of ventilation heterogeneity were present in both healthy and reactive mild-to-moderate asthmatic subjects after MCh challenge, but a refractory response to DI's clearly characterized the images of asthmatic ventilation. When the same techniques were applied to subjects with a past history of chronic asthma but who were no longer reactive, it was found that they, too, were unable to achieve bronchodilation with DI's. This suggests the presence of permanent airway remodeling, which either results in impaired ability for the airway smooth muscle to relax once bronchoconstriction is established, or stiffer airway walls inhibiting dilation of narrowed airways.
590 $a School code: 0017.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0541
690 $a 0574
710 2 $a Boston University. $3 1017454
773 0 $t Dissertation Abstracts International $g 68-08B.
790 $a 0017
790 1 0 $a Lutchen, Kenneth R., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3279974