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Surfactant-free biodegradable nanopa...

Nehilla, Barrett James.

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Surfactant-free biodegradable nanoparticles for antioxidant drug delivery and imaging applications.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Surfactant-free biodegradable nanoparticles for antioxidant drug delivery and imaging applications./
Author:	Nehilla, Barrett James.
Description:	173 p.
Notes:	Adviser: Tejal A. Desai.
Contained By:	Dissertation Abstracts International68-08B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3279948
ISBN:	9780549210849

Surfactant-free biodegradable nanoparticles for antioxidant drug delivery and imaging applications.
Nehilla, Barrett James.

Surfactant-free biodegradable nanoparticles for antioxidant drug delivery and imaging applications. - 173 p.

Adviser: Tejal A. Desai.

Thesis (Ph.D.)--Boston University, 2008.

Diseases caused by neurodegeneration (e.g., Parkinson's Disease (PD)) afflict millions of Americans. The incidence of these age-related diseases and their associated costs will increase concomitantly with the U.S. life expectancy. Currently, therapy for PD is palliative and symptomatic. Therefore, innovative approaches for preventive therapy are needed. Because of the compelling evidence linking oxidative stress and PD, preventive therapy may be achieved with antioxidants like Coenzyme Q10 (CoQ10). CoQ10 could hinder the progression of neurodegeneration by attenuating underlying oxidative stress rather than simply alleviating symptoms, but it is extremely difficult to administer. Although antioxidant and neuronal drug delivery have been rarely studied, drug delivery platforms that integrate bioengineering, pharmacology and nanotechnology may revolutionize pharmaceutical therapies. Drug-loaded, biodegradable poly(lactide-co-glycolide) (PLGA) nanoparticles have many advantages over conventional drug therapy, and the current antioxidant (CoQ10)-loaded biodegradable nanoparticles may significantly enhance neuronal antioxidant drug therapy. This thesis investigated a nanoparticle-based drug delivery approach to attenuating the oxidative damage associated with PD.

ISBN: 9780549210849Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Surfactant-free biodegradable nanoparticles for antioxidant drug delivery and imaging applications.
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020 $a 9780549210849
035 $a (UMI)AAI3279948
035 $a AAI3279948
040 $a UMI $c UMI
100 1 $a Nehilla, Barrett James. $3 1280974
245 1 0 $a Surfactant-free biodegradable nanoparticles for antioxidant drug delivery and imaging applications.
300 $a 173 p.
500 $a Adviser: Tejal A. Desai.
500 $a Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5394.
502 $a Thesis (Ph.D.)--Boston University, 2008.
520 $a Diseases caused by neurodegeneration (e.g., Parkinson's Disease (PD)) afflict millions of Americans. The incidence of these age-related diseases and their associated costs will increase concomitantly with the U.S. life expectancy. Currently, therapy for PD is palliative and symptomatic. Therefore, innovative approaches for preventive therapy are needed. Because of the compelling evidence linking oxidative stress and PD, preventive therapy may be achieved with antioxidants like Coenzyme Q10 (CoQ10). CoQ10 could hinder the progression of neurodegeneration by attenuating underlying oxidative stress rather than simply alleviating symptoms, but it is extremely difficult to administer. Although antioxidant and neuronal drug delivery have been rarely studied, drug delivery platforms that integrate bioengineering, pharmacology and nanotechnology may revolutionize pharmaceutical therapies. Drug-loaded, biodegradable poly(lactide-co-glycolide) (PLGA) nanoparticles have many advantages over conventional drug therapy, and the current antioxidant (CoQ10)-loaded biodegradable nanoparticles may significantly enhance neuronal antioxidant drug therapy. This thesis investigated a nanoparticle-based drug delivery approach to attenuating the oxidative damage associated with PD.
520 $a Nanoprecipitation yielded surfactant-free, empty and loaded biodegradable PLGA nanoparticles with controllable physical and CoQ10 encapsulation properties. CoQ10 release from the nanoparticles was sustained for two weeks. A novel methodology was developed to purify surfactant-free nanoparticles, which did not alter the diameter, polydispersity, morphology, CoQ10 encapsulation or surfactant-free characteristics of the CoQ10-loaded nanoparticles. Successful purification of surfactant-free nanoparticles from unencapsulated molecules (CoQ10 or QDs) was a major contribution of this work. Biocompatible, quantum dot (QD)-loaded nanoparticles were also developed and utilized to elucidate nanoparticle-cell interactions via confocal microscopy. The synthesis of novel CoQ10-QD co-loaded nanoparticles represented a first step toward simultaneous drug delivery and cell imaging with a single, multifunctional nanoparticle platform.
520 $a Additionally, an in vitro model of long-term, oxidative stress-induced dopaminergic neurodegeneration was developed. First, time-dependent development of rotenone-induced cytotoxicity, lipid peroxidation and antioxidant alterations was established in differentiated PC12 cells. Purified, CoQ10-loaded nanoparticles were applied in this cell model and were biocompatible to 60 mug/mL. More importantly, these nanoparticles exhibited trends of attenuating cytotoxicity and oxidative stress in the rotenone-damaged PC12 cells. These novel surfactant-free, loaded nanoparticles have utility and promise in both drug delivery and cell imaging applications.
590 $a School code: 0017.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0419
690 $a 0541
710 2 $a Boston University. $3 1017454
773 0 $t Dissertation Abstracts International $g 68-08B.
790 $a 0017
790 1 0 $a Desai, Tejal A., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3279948