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The design, characteristics, and app...

Kampeerapappun, Piyaporn.

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The design, characteristics, and application of polyurethane dressings using the electrospinning process.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The design, characteristics, and application of polyurethane dressings using the electrospinning process./
Author:	Kampeerapappun, Piyaporn.
Description:	185 p.
Notes:	Adviser: Daniel J. Smith.
Contained By:	Dissertation Abstracts International69-03B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3308504
ISBN:	9780549554400

The design, characteristics, and application of polyurethane dressings using the electrospinning process.
Kampeerapappun, Piyaporn.

The design, characteristics, and application of polyurethane dressings using the electrospinning process. - 185 p.

Adviser: Daniel J. Smith.

Thesis (Ph.D.)--The University of Akron, 2008.

In general, a dressing is used to protect and help heal wounds. There are several types of dressings on the market such as hydrocolloid, hydrogel, and medicated dressings. One technique for making a dressing is electrospinning, which is a very simple procedure used to produce fibers. Due to much smaller fiber-diameters than produced with the conventional technique, the fibers from electrospinning have unique properties: high porosity and high surface areas, which are advantageous for wound healing.

ISBN: 9780549554400Subjects--Topical Terms:

1018428
Chemistry, Polymer.

The design, characteristics, and application of polyurethane dressings using the electrospinning process.
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020 $a 9780549554400
035 $a (UMI)AAI3308504
035 $a AAI3308504
040 $a UMI $c UMI
100 1 $a Kampeerapappun, Piyaporn. $3 1280803
245 1 4 $a The design, characteristics, and application of polyurethane dressings using the electrospinning process.
300 $a 185 p.
500 $a Adviser: Daniel J. Smith.
500 $a Source: Dissertation Abstracts International, Volume: 69-03, Section: B, page: 1677.
502 $a Thesis (Ph.D.)--The University of Akron, 2008.
520 $a In general, a dressing is used to protect and help heal wounds. There are several types of dressings on the market such as hydrocolloid, hydrogel, and medicated dressings. One technique for making a dressing is electrospinning, which is a very simple procedure used to produce fibers. Due to much smaller fiber-diameters than produced with the conventional technique, the fibers from electrospinning have unique properties: high porosity and high surface areas, which are advantageous for wound healing.
520 $a In this research, the fibers were electrospun using polyurethane, TecophilicRTM or TecoflexRTM, with various additives. First, multilayer transdermal electrospun dressings, four and five-layers, were developed that allowed for the controlled release of nitric oxide (NO) from a NO2 -/ascorbic acid system encapsulated in polymer nanofibers. The amount of NO released from each wound dressing was investigated. Both the four and five-layer dressings were tested for morphology of fibers, water absorption, nitrite distribution, NO release profile after sterilization by gamma radiation, and stability. In the case of the four-layer transdermal dressing, the dressing was tested in diabetic, periodontal, and cutaneous leishmaniasis patients. Furthermore, the color change of dressing was investigated.
520 $a TecophilicRTM was also spun with an antimicrobial agent, which was added to the TecophilicRTM solution to electrospin an antimicrobial dressing. The morphology of fibers was tested using an optical microscope and the water absorption, uniformity, and percent extraction of dressing were also determined. In addition, the efficiency of the antimicrobial agent in the dressing was determined according to SN 195920-1994 and ASTM 2149-01.
520 $a Another NO-releasing dressing was developed employing the NO donor molecules, sodium salt of linear polyethylenimine NONOates (LPEINO-Na) and calcium salt of linear polyethylenimine NONOates (LPEINO-Ca), which were electrospun with TecophilicRTM. The NO release profiles for the LPEINO fibers were generated using a nitric oxide analyzer (NOA) and distribution of the particles in the dressing was examined. Moreover, the amount of NO released after patch storage for 1 and 2 months was determined.
590 $a School code: 0003.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Materials Science. $3 1017759
690 $a 0495
690 $a 0794
710 2 $a The University of Akron. $3 1018399
773 0 $t Dissertation Abstracts International $g 69-03B.
790 $a 0003
790 1 0 $a Smith, Daniel J., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3308504