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Influence of hydrodynamic stresses, ...

Yalcin, Huseyin Cagatay.

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Influence of hydrodynamic stresses, cellular mechanics and environmental conditions on epithelial cell injury during airway reopening.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Influence of hydrodynamic stresses, cellular mechanics and environmental conditions on epithelial cell injury during airway reopening./
Author:	Yalcin, Huseyin Cagatay.
Description:	182 p.
Notes:	Adviser: Samir N. Ghadiali.
Contained By:	Dissertation Abstracts International68-10B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3285736
ISBN:	9780549277439

Influence of hydrodynamic stresses, cellular mechanics and environmental conditions on epithelial cell injury during airway reopening.
Yalcin, Huseyin Cagatay.

Influence of hydrodynamic stresses, cellular mechanics and environmental conditions on epithelial cell injury during airway reopening. - 182 p.

Adviser: Samir N. Ghadiali.

Thesis (Ph.D.)--Lehigh University, 2007.

Acute Respiratory Distress Syndrome (ARDS) is a common and devastating lung disorder. In spite of the tremendous amount of research on this subject, many of the mechanisms responsible for the initiation and progression of this disease are not understood. Although the mechanical forces generated by ventilating patients with large volumes have been investigated, the consequences of the fluid mechanical and surface tension forces generated at low lung volumes as well as the role of cellular mechanics on this disease is unknown. The main objective of this dissertation research is to design and implement an in-vitro cell culture model in order to investigate the responses of lung epithelial cells (EC) to the fluid mechanical forces generated during the low lung volume ventilation of ARDS patients. In this model, the collapse and reopening of small airways is mimicked by progressing micron sized air bubbles over EC populations. EC were found to be very sensitive to the hydrodynamic stresses, especially to large spatial gradients in pressure near the bubble tip during bubble progressions. Additionally, compared to single bubble propagation, multiple bubble passages created additional injury, but the most of the injury happened after the first bubble propagation. In addition to hydrodynamic stresses, EC' morphological, biomechanical and microstructural properties also played a major role on cellular injury during bubble progressions. As these cells become more liquid-like, their resistance to injurious stresses increases significantly. The knowledge gained from this study may be useful to understand the injury mechanisms of EC during low volume ventilation and therefore to establish new ventilatory protocols and pharmaceutical treatments for ARDS patients.

ISBN: 9780549277439Subjects--Topical Terms:

1017686
Biology, Cell.

Influence of hydrodynamic stresses, cellular mechanics and environmental conditions on epithelial cell injury during airway reopening.
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020 $a 9780549277439
035 $a (UMI)AAI3285736
035 $a AAI3285736
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100 1 $a Yalcin, Huseyin Cagatay. $3 1279959
245 1 0 $a Influence of hydrodynamic stresses, cellular mechanics and environmental conditions on epithelial cell injury during airway reopening.
300 $a 182 p.
500 $a Adviser: Samir N. Ghadiali.
500 $a Source: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6803.
502 $a Thesis (Ph.D.)--Lehigh University, 2007.
520 $a Acute Respiratory Distress Syndrome (ARDS) is a common and devastating lung disorder. In spite of the tremendous amount of research on this subject, many of the mechanisms responsible for the initiation and progression of this disease are not understood. Although the mechanical forces generated by ventilating patients with large volumes have been investigated, the consequences of the fluid mechanical and surface tension forces generated at low lung volumes as well as the role of cellular mechanics on this disease is unknown. The main objective of this dissertation research is to design and implement an in-vitro cell culture model in order to investigate the responses of lung epithelial cells (EC) to the fluid mechanical forces generated during the low lung volume ventilation of ARDS patients. In this model, the collapse and reopening of small airways is mimicked by progressing micron sized air bubbles over EC populations. EC were found to be very sensitive to the hydrodynamic stresses, especially to large spatial gradients in pressure near the bubble tip during bubble progressions. Additionally, compared to single bubble propagation, multiple bubble passages created additional injury, but the most of the injury happened after the first bubble propagation. In addition to hydrodynamic stresses, EC' morphological, biomechanical and microstructural properties also played a major role on cellular injury during bubble progressions. As these cells become more liquid-like, their resistance to injurious stresses increases significantly. The knowledge gained from this study may be useful to understand the injury mechanisms of EC during low volume ventilation and therefore to establish new ventilatory protocols and pharmaceutical treatments for ARDS patients.
590 $a School code: 0105.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0379
690 $a 0541
690 $a 0760
710 2 $a Lehigh University. $3 515436
773 0 $t Dissertation Abstracts International $g 68-10B.
790 $a 0105
790 1 0 $a Ghadiali, Samir N., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3285736