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Photochemical and photophysical inve...

Neuman, Daniel.

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Photochemical and photophysical investigations of newly designed supramolecular structures composed of quantum dots and nitric oxide donors.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Photochemical and photophysical investigations of newly designed supramolecular structures composed of quantum dots and nitric oxide donors./
Author:	Neuman, Daniel.
Description:	202 p.
Notes:	Adviser: Peter C. Ford.
Contained By:	Dissertation Abstracts International68-03B.
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3255188

Photochemical and photophysical investigations of newly designed supramolecular structures composed of quantum dots and nitric oxide donors.
Neuman, Daniel.

Photochemical and photophysical investigations of newly designed supramolecular structures composed of quantum dots and nitric oxide donors. - 202 p.

Adviser: Peter C. Ford.

Thesis (Ph.D.)--University of California, Santa Barbara, 2007.

Nitric oxide (NO), a ubiquitous messenger molecule in mammalian physiology, is also known to act as a potent gamma-radiation sensitizer. For this reason, there is considerable interest in the development of thermally stable compounds capable of controllably releasing NO. Such compounds could see broad application for the enhancement of existing cancer treatment strategies. In this context, photochemically activated NO precursors are attractive given the opportunity to control the location and timing of the signal leading to release of NO. With this in mind, the work described here exploits the extraordinary light absorbing capabilities of semiconductor quantum dots (QDs) both in the single photon excitation (SPE) and two photon excitation (TPE) regimes and demonstrates their potential applicability as photosensitizers for NO releasing prodrugs.Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Photochemical and photophysical investigations of newly designed supramolecular structures composed of quantum dots and nitric oxide donors.
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005 20110624
008 110624s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI3255188
035 $a AAI3255188
040 $a UMI $c UMI
100 1 $a Neuman, Daniel. $3 1279907
245 1 0 $a Photochemical and photophysical investigations of newly designed supramolecular structures composed of quantum dots and nitric oxide donors.
300 $a 202 p.
500 $a Adviser: Peter C. Ford.
500 $a Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1631.
502 $a Thesis (Ph.D.)--University of California, Santa Barbara, 2007.
520 $a Nitric oxide (NO), a ubiquitous messenger molecule in mammalian physiology, is also known to act as a potent gamma-radiation sensitizer. For this reason, there is considerable interest in the development of thermally stable compounds capable of controllably releasing NO. Such compounds could see broad application for the enhancement of existing cancer treatment strategies. In this context, photochemically activated NO precursors are attractive given the opportunity to control the location and timing of the signal leading to release of NO. With this in mind, the work described here exploits the extraordinary light absorbing capabilities of semiconductor quantum dots (QDs) both in the single photon excitation (SPE) and two photon excitation (TPE) regimes and demonstrates their potential applicability as photosensitizers for NO releasing prodrugs.
520 $a In this dissertation, new supramolecular structures will be described that are composed of chromium(III) complexes of cyclam (cyclam = 1,4,8,11-tetraazacyclotetradecane) both covalently bound to and electrostatically assembled on the surface of water soluble CdSe/ZnS QDs. Previous studies on the nitrito (ONO) derivatives of the chromium cyclam complexes indicated that they are photo-labile towards release of NO with quantum yields as high as 50%. However, these complexes lack absorption at long wavelengths (>600 run) where biological tissue penetration is enhanced. Investigations of the electrostatic assemblies in aqueous solution demonstrate that the Cr(III) complexes quench the QD photoluminescence (PL) obtained via either SPE (366-546 nm) or TPE (800 nm) excitation in a concentration dependent manner. Furthermore, in the electrostatic assemblies containing the dinitrito trans-Cr(cyclam)(ONO) 2+ cation and CdSe/ZnS QDs, photolysis of the assembly results in enhanced photochemical NO release (up to 50 fold more) as compared to the Cr(III) complexes alone. The photophysical and photochemical properties of these QD/chromium(III) cyclam structures are the subjects of this dissertation.
590 $a School code: 0035.
650 4 $a Chemistry, Inorganic. $3 517253
690 $a 0488
710 2 $a University of California, Santa Barbara. $3 1017586
773 0 $t Dissertation Abstracts International $g 68-03B.
790 $a 0035
790 1 0 $a Ford, Peter C., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3255188