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Health-related fitness, physical act...

Krasnoff, Joanne B.

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Health-related fitness, physical activity, and non-alcoholic fatty liver disease.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Health-related fitness, physical activity, and non-alcoholic fatty liver disease./
Author:	Krasnoff, Joanne B.
Description:	408 p.
Notes:	Adviser: Janet P. Wallace.
Contained By:	Dissertation Abstracts International68-07B.
Subject:	Biology, Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3274261
ISBN:	9780549151357

Health-related fitness, physical activity, and non-alcoholic fatty liver disease.
Krasnoff, Joanne B.

Health-related fitness, physical activity, and non-alcoholic fatty liver disease. - 408 p.

Adviser: Janet P. Wallace.

Thesis (Ph.D.)--Indiana University, 2007.

Nonalcoholic fatty liver disease (NAFLD) has been referred to as the hepatic manifestation of the metabolic syndrome (MS). There is a lower prevalence of MS in individuals with higher health-related fitness (HRF) and physical activity (PA) participation. The relationship between NAFLD severity and HRF and PA is unknown. The purpose of this study was to document and compare measures of HRF and PA in patients with a histological spectrum of NAFLD. Thirty-seven patients with liver biopsy confirmed-NAFLD (18F/19M; age = 45.9 +/- 12.7 yr) completed assessment of cardiorespiratory fitness (CRF, VO2peak), muscle strength (quadriceps peak torque), and body composition (%fat). Current and historical PA was also assessed. Liver histology classified NAFLD severity by steatosis (mild, moderate, severe), fibrosis stage (stage 1 vs. stage 2/3), necroinflammatory activity (NAFLD Activity Score; ≤ 4, NAS1 vs. ≥ 5, NAS2) and diagnosis of nonalcoholic steatohepatitis by Brunt criteria (NASH vs. NotNASH). ANOVA and independent t-tests were used to determine the differences among the various groups. Less than 20% of the patients met recommended guidelines for PA and 97.3% were classified as increased risk of morbidity and mortality by %fat. No differences were detected in VO2peak (x=26.8 +/- 7.4 ml/kg/min) or %fat (x=38.6 +/- 8.2%) among the steatosis or fibrosis groups. Peak VO2 was higher in the NAS1 vs. NAS2 (p=0.013) and notNASH vs. the NASH (p= 0.048). Patients with NAFLD of differing severity have sub-optimal HRF. CRF was significantly worse in those with NASH and greater NAS. Lifestyle interventions to improve HRF may be beneficial in reducing the associated risk factors and preventing progression of NAFLD.

ISBN: 9780549151357Subjects--Topical Terms:

1017816
Biology, Physiology.

Health-related fitness, physical activity, and non-alcoholic fatty liver disease.
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035 $a (UMI)AAI3274261
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040 $a UMI $c UMI
100 1 $a Krasnoff, Joanne B. $3 1278552
245 1 0 $a Health-related fitness, physical activity, and non-alcoholic fatty liver disease.
300 $a 408 p.
500 $a Adviser: Janet P. Wallace.
500 $a Source: Dissertation Abstracts International, Volume: 68-07, Section: B, page: 4315.
502 $a Thesis (Ph.D.)--Indiana University, 2007.
520 $a Nonalcoholic fatty liver disease (NAFLD) has been referred to as the hepatic manifestation of the metabolic syndrome (MS). There is a lower prevalence of MS in individuals with higher health-related fitness (HRF) and physical activity (PA) participation. The relationship between NAFLD severity and HRF and PA is unknown. The purpose of this study was to document and compare measures of HRF and PA in patients with a histological spectrum of NAFLD. Thirty-seven patients with liver biopsy confirmed-NAFLD (18F/19M; age = 45.9 +/- 12.7 yr) completed assessment of cardiorespiratory fitness (CRF, VO2peak), muscle strength (quadriceps peak torque), and body composition (%fat). Current and historical PA was also assessed. Liver histology classified NAFLD severity by steatosis (mild, moderate, severe), fibrosis stage (stage 1 vs. stage 2/3), necroinflammatory activity (NAFLD Activity Score; ≤ 4, NAS1 vs. ≥ 5, NAS2) and diagnosis of nonalcoholic steatohepatitis by Brunt criteria (NASH vs. NotNASH). ANOVA and independent t-tests were used to determine the differences among the various groups. Less than 20% of the patients met recommended guidelines for PA and 97.3% were classified as increased risk of morbidity and mortality by %fat. No differences were detected in VO2peak (x=26.8 +/- 7.4 ml/kg/min) or %fat (x=38.6 +/- 8.2%) among the steatosis or fibrosis groups. Peak VO2 was higher in the NAS1 vs. NAS2 (p=0.013) and notNASH vs. the NASH (p= 0.048). Patients with NAFLD of differing severity have sub-optimal HRF. CRF was significantly worse in those with NASH and greater NAS. Lifestyle interventions to improve HRF may be beneficial in reducing the associated risk factors and preventing progression of NAFLD.
590 $a School code: 0093.
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Health Sciences, Recreation. $3 1018003
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3274261