東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Signaling and transcriptional mechan...

Titolo, Danny.

FindBook

Google Book

Amazon

博客來

Signaling and transcriptional mechanisms involved in the control of GnRH and NPY by estrogen.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Signaling and transcriptional mechanisms involved in the control of GnRH and NPY by estrogen./
作者:	Titolo, Danny.
面頁冊數:	131 p.
附註:	Source: Masters Abstracts International, Volume: 45-06, page: 3063.
Contained By:	Masters Abstracts International45-06.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR27504
ISBN:	9780494275047

Signaling and transcriptional mechanisms involved in the control of GnRH and NPY by estrogen.
Titolo, Danny.

Signaling and transcriptional mechanisms involved in the control of GnRH and NPY by estrogen. - 131 p.

Source: Masters Abstracts International, Volume: 45-06, page: 3063.

Thesis (M.Sc.)--University of Toronto (Canada), 2007.

Neuropeptide Y (NPY) is involved in the regulation of energy homeostasis and reproductive function. Using two immortalized hypothalamic cell lines expressing NPY, N-38 and N-42, and one expressing gonadotropin-releasing hormone (GnRH), GT1-7, we demonstrate that 17beta-estradiol (E2) differentially regulates estrogen receptor (ER)alpha and ERbeta mRNA levels while NPY mRNA is temporally correlated with the changes in ER mRNA. The regulation of NPY gene expression can be mapped to within -97 bp of the NPY promoter in N-38 cells. E2 also activates the P13-K and MAPK signaling pathways and inhibition of these pathways results in attenuation of E2-mediated effects on NPY gene expression. Finally, using immunocytochemistry we demonstrate that both ERalpha and ERbeta are present at the plasma membrane in N-38 cells. These studies indicate that E2 can directly regulate NPY gene expression in hypothalamic cell models which includes cellular mechanisms ranging from nuclear to membrane-mediated action.

ISBN: 9780494275047Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Signaling and transcriptional mechanisms involved in the control of GnRH and NPY by estrogen.
LDR:01804nam 2200253 a 45 001 949739
005 20110525
008 110525s2007 eng d
020 $a 9780494275047
035 $a (UMI)AAIMR27504
035 $a AAIMR27504
040 $a UMI $c UMI
100 1 $a Titolo, Danny. $3 1273133
245 1 0 $a Signaling and transcriptional mechanisms involved in the control of GnRH and NPY by estrogen.
300 $a 131 p.
500 $a Source: Masters Abstracts International, Volume: 45-06, page: 3063.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2007.
520 $a Neuropeptide Y (NPY) is involved in the regulation of energy homeostasis and reproductive function. Using two immortalized hypothalamic cell lines expressing NPY, N-38 and N-42, and one expressing gonadotropin-releasing hormone (GnRH), GT1-7, we demonstrate that 17beta-estradiol (E2) differentially regulates estrogen receptor (ER)alpha and ERbeta mRNA levels while NPY mRNA is temporally correlated with the changes in ER mRNA. The regulation of NPY gene expression can be mapped to within -97 bp of the NPY promoter in N-38 cells. E2 also activates the P13-K and MAPK signaling pathways and inhibition of these pathways results in attenuation of E2-mediated effects on NPY gene expression. Finally, using immunocytochemistry we demonstrate that both ERalpha and ERbeta are present at the plasma membrane in N-38 cells. These studies indicate that E2 can directly regulate NPY gene expression in hypothalamic cell models which includes cellular mechanisms ranging from nuclear to membrane-mediated action.
590 $a School code: 0779.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0433
710 2 0 $a University of Toronto (Canada). $3 1017674
773 0 $t Masters Abstracts International $g 45-06.
790 $a 0779
791 $a M.Sc.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR27504