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Polymeric micro/nanofibers: Fabricat...

Nain, Amrinder Singh.

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Polymeric micro/nanofibers: Fabrication, aligned deposition, mechanical characterization, and biological applications.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Polymeric micro/nanofibers: Fabrication, aligned deposition, mechanical characterization, and biological applications./
Author:	Nain, Amrinder Singh.
Description:	264 p.
Notes:	Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 6256.
Contained By:	Dissertation Abstracts International68-09B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3282365
ISBN:	9780549241768

Polymeric micro/nanofibers: Fabrication, aligned deposition, mechanical characterization, and biological applications.
Nain, Amrinder Singh.

Polymeric micro/nanofibers: Fabrication, aligned deposition, mechanical characterization, and biological applications. - 264 p.

Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 6256.

Thesis (Ph.D.)--Carnegie Mellon University, 2007.

Precise manufacturing of nanofibers is an essential bottom-up manufacturing technique in nano environment and polymeric micro/nanofibers offer several advantages over other materials. In this work, we have developed two techniques for repeatable fabrication of precisely aligned polymeric fibers of polystyrene (PS) and poly (methyl methacrylate) (PMMA) with diameters ranging from sub 50 nm to few microns and several millimeters in length. For the first time, dependency of properties of the fabricated micro/nanofibers on solution rheological properties and molecular weight are mapped in accordance with theoretical predictions. Mechanical properties of the deposited aligned fibers, as small as 34 nm in diameter, with fixed-fixed boundary conditions are characterized using state-of-the-art atomic force microscopy and electron microscopy. Resonance frequency measurements of the deposited fibers are in agreement with analytical models and are shown to estimate the Young's modulus of sub-micron fibers. Finally, Spinneret based Tunable Engineered Parameters (STEP) technique has been developed for fabricating single and multi-layer biomaterial scaffolds. Scaffolds are successfully seeded with mouse pluripotential cells for tissue engineering applications and the geometrical constraints of diverging fibers in single layer scaffolds and intersecting fibers (right angle) have provided new insights into cellular dynamics and the design of future aligned biomaterial scaffolds.

ISBN: 9780549241768Subjects--Topical Terms:

1017681
Biophysics, Medical.

Polymeric micro/nanofibers: Fabrication, aligned deposition, mechanical characterization, and biological applications.
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008 110525s2007 ||||||||||||||||| ||eng d
020 $a 9780549241768
035 $a (UMI)AAI3282365
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100 1 $a Nain, Amrinder Singh. $3 1272208
245 1 0 $a Polymeric micro/nanofibers: Fabrication, aligned deposition, mechanical characterization, and biological applications.
300 $a 264 p.
500 $a Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 6256.
502 $a Thesis (Ph.D.)--Carnegie Mellon University, 2007.
520 $a Precise manufacturing of nanofibers is an essential bottom-up manufacturing technique in nano environment and polymeric micro/nanofibers offer several advantages over other materials. In this work, we have developed two techniques for repeatable fabrication of precisely aligned polymeric fibers of polystyrene (PS) and poly (methyl methacrylate) (PMMA) with diameters ranging from sub 50 nm to few microns and several millimeters in length. For the first time, dependency of properties of the fabricated micro/nanofibers on solution rheological properties and molecular weight are mapped in accordance with theoretical predictions. Mechanical properties of the deposited aligned fibers, as small as 34 nm in diameter, with fixed-fixed boundary conditions are characterized using state-of-the-art atomic force microscopy and electron microscopy. Resonance frequency measurements of the deposited fibers are in agreement with analytical models and are shown to estimate the Young's modulus of sub-micron fibers. Finally, Spinneret based Tunable Engineered Parameters (STEP) technique has been developed for fabricating single and multi-layer biomaterial scaffolds. Scaffolds are successfully seeded with mouse pluripotential cells for tissue engineering applications and the geometrical constraints of diverging fibers in single layer scaffolds and intersecting fibers (right angle) have provided new insights into cellular dynamics and the design of future aligned biomaterial scaffolds.
590 $a School code: 0041.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Mechanical. $3 783786
690 $a 0495
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710 2 $a Carnegie Mellon University. $3 1018096
773 0 $t Dissertation Abstracts International $g 68-09B.
790 $a 0041
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3282365