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Bioinformatic and experimental analy...

Pearson, Joseph Carlisle.

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Bioinformatic and experimental analysis of hox and epidermal wound response enhancers in Drosophila.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Bioinformatic and experimental analysis of hox and epidermal wound response enhancers in Drosophila./
Author:	Pearson, Joseph Carlisle.
Description:	191 p.
Notes:	Adviser: William McGinnis.
Contained By:	Dissertation Abstracts International68-04B.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3259363

Bioinformatic and experimental analysis of hox and epidermal wound response enhancers in Drosophila.
Pearson, Joseph Carlisle.

Bioinformatic and experimental analysis of hox and epidermal wound response enhancers in Drosophila. - 191 p.

Adviser: William McGinnis.

Thesis (Ph.D.)--University of California, San Diego, 2007.

Unlike the well-known correspondence between the mRNA sequence blueprint and the protein encoded from it, fairly little is understood about how cis-regulatory elements, the DNA sequences that control when and where mRNAs are expressed, are structured to exert their influence. Even genes with well-conserved expression patterns in distantly related organisms, such as Dll in developing limbs of protostomes and deuterostomes, are controlled by largely unknown mechanisms. The number of techniques available for understanding cis-regulation is expanding rapidly, but each one has severe limitations. In an attempt to improve the rate of cis-regulatory discovery, I have combined molecular biological and in silico techniques to study two cis-regulatory paradigms in Drosophila. To dissect the cis-regulatory mechanisms controlling Dll limb expression in insects, I used germline transformation and bioinformatics to identify several novel motifs required for embryonic limb expression of Dll. Based on the techniques developed studying Dll, I have extended previous research dissecting a cis-regulatory element controlling Ddc wound-induced expression. I have identified a battery of wound-response genes, including the particular cis-regulatory elements controlling wound-responsive expression. These elements reveal complex regulatory interactions that result in the induction of a diverse set of genes required for various aspects of Drosophila wound healing.Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Bioinformatic and experimental analysis of hox and epidermal wound response enhancers in Drosophila.
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035 $a (UMI)AAI3259363
035 $a AAI3259363
040 $a UMI $c UMI
100 1 $a Pearson, Joseph Carlisle. $3 1271035
245 1 0 $a Bioinformatic and experimental analysis of hox and epidermal wound response enhancers in Drosophila.
300 $a 191 p.
500 $a Adviser: William McGinnis.
500 $a Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2091.
502 $a Thesis (Ph.D.)--University of California, San Diego, 2007.
520 $a Unlike the well-known correspondence between the mRNA sequence blueprint and the protein encoded from it, fairly little is understood about how cis-regulatory elements, the DNA sequences that control when and where mRNAs are expressed, are structured to exert their influence. Even genes with well-conserved expression patterns in distantly related organisms, such as Dll in developing limbs of protostomes and deuterostomes, are controlled by largely unknown mechanisms. The number of techniques available for understanding cis-regulation is expanding rapidly, but each one has severe limitations. In an attempt to improve the rate of cis-regulatory discovery, I have combined molecular biological and in silico techniques to study two cis-regulatory paradigms in Drosophila. To dissect the cis-regulatory mechanisms controlling Dll limb expression in insects, I used germline transformation and bioinformatics to identify several novel motifs required for embryonic limb expression of Dll. Based on the techniques developed studying Dll, I have extended previous research dissecting a cis-regulatory element controlling Ddc wound-induced expression. I have identified a battery of wound-response genes, including the particular cis-regulatory elements controlling wound-responsive expression. These elements reveal complex regulatory interactions that result in the induction of a diverse set of genes required for various aspects of Drosophila wound healing.
590 $a School code: 0033.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0715
710 2 $a University of California, San Diego. $3 1018093
773 0 $t Dissertation Abstracts International $g 68-04B.
790 $a 0033
790 1 0 $a McGinnis, William, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3259363