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Hox targeting in vertebrate forelimb...

Greer, Lee Fitzhugh, III.

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Hox targeting in vertebrate forelimb induction: Expression and comparative genomics.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Hox targeting in vertebrate forelimb induction: Expression and comparative genomics./
Author:	Greer, Lee Fitzhugh, III.
Description:	338 p.
Notes:	Adviser: Kerby Oberg.
Contained By:	Dissertation Abstracts International68-01B.
Subject:	Biology, Anatomy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3250187

Hox targeting in vertebrate forelimb induction: Expression and comparative genomics.
Greer, Lee Fitzhugh, III.

Hox targeting in vertebrate forelimb induction: Expression and comparative genomics. - 338 p.

Adviser: Kerby Oberg.

Thesis (Ph.D.)--Loma Linda University, 2007.

Hox genes encode master regulators of body plan during embryonic development. In land and avian (bird) vertebrates there are four clusters of Hox genes (A, B, C, D). Patterns of Hox expression (paralogs 5-8), in our work specifically Hoxc5, c6, c8, and Hoxd8 in the forelimb forelimb area have been determined, using the chicken (Gallus gallus) as our model organism. These data help complete the known Hox gene expression patterns for early forelimb development for all four land and avian vertebrates. Potential Hox, Hox-associated, and homeodornain core binding sites in genes inducing the forelimb (Tbx5, Sall1, Sall4, and Fgf10) have been predicted through comparative genomics, including the use of sequence alignment, phylogenetic footprinting, and related analyses. We have also used comparative genomics to predict potential Lmx1b core binding sites in the Emx2 gene. Both Lmx1b and Emx2 are factors involved in forelimb and shoulder girdle dorsalization.Subjects--Topical Terms:

1021727
Biology, Anatomy.

Hox targeting in vertebrate forelimb induction: Expression and comparative genomics.
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100 1 $a Greer, Lee Fitzhugh, III. $3 1270997
245 1 0 $a Hox targeting in vertebrate forelimb induction: Expression and comparative genomics.
300 $a 338 p.
500 $a Adviser: Kerby Oberg.
500 $a Source: Dissertation Abstracts International, Volume: 68-01, Section: B, page: 0022.
502 $a Thesis (Ph.D.)--Loma Linda University, 2007.
520 $a Hox genes encode master regulators of body plan during embryonic development. In land and avian (bird) vertebrates there are four clusters of Hox genes (A, B, C, D). Patterns of Hox expression (paralogs 5-8), in our work specifically Hoxc5, c6, c8, and Hoxd8 in the forelimb forelimb area have been determined, using the chicken (Gallus gallus) as our model organism. These data help complete the known Hox gene expression patterns for early forelimb development for all four land and avian vertebrates. Potential Hox, Hox-associated, and homeodornain core binding sites in genes inducing the forelimb (Tbx5, Sall1, Sall4, and Fgf10) have been predicted through comparative genomics, including the use of sequence alignment, phylogenetic footprinting, and related analyses. We have also used comparative genomics to predict potential Lmx1b core binding sites in the Emx2 gene. Both Lmx1b and Emx2 are factors involved in forelimb and shoulder girdle dorsalization.
590 $a School code: 0106.
650 4 $a Biology, Anatomy. $3 1021727
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
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710 2 $a Loma Linda University. $3 1020166
773 0 $t Dissertation Abstracts International $g 68-01B.
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791 $a Ph.D.
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3250187