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Evaluation of biodegradable and elec...

Wang, Zhaoxu.

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Evaluation of biodegradable and electrically conductive polymers based on polylactide and polypyrrole.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Evaluation of biodegradable and electrically conductive polymers based on polylactide and polypyrrole./
作者:	Wang, Zhaoxu.
面頁冊數:	186 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4349.
Contained By:	Dissertation Abstracts International66-08B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR05599
ISBN:	9780494055991

Evaluation of biodegradable and electrically conductive polymers based on polylactide and polypyrrole.
Wang, Zhaoxu.

Evaluation of biodegradable and electrically conductive polymers based on polylactide and polypyrrole. - 186 p.

Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4349.

Thesis (Ph.D.)--Universite Laval (Canada), 2005.

This thesis studied the potential of new biodegradable and electrically conductive polymers for vascular and tissue engineering applications. Newly synthesized poly(epsilon-caprolactone/poly(ethylene glycol)/L-lactide) (PCEL) and electrically conductive biodegradable polymer composite (PPy/PDLLA) were examined both in vitro and in vivo to determine their biodegradation, biocompatibility, and electrical stability. Results show that the uniform degradation of the PCEL in simple hydrolysis was as slow as that observed with PLLA. In the presence of pancreatin, the PCEL showed heterogeneous degradation. The PCEL impregnated as a sealant in vascular prostheses induced a mild inflammation in vivo in a subcutaneous model, comparable to the reactions with other clinically used biodegradable polymers. The PPy/PDLLA composite showed sufficient electrical stability to serve as a template for electrical stimulation in a biologically relevant environment. The tissue reaction of the PPy/PDLLA composite was similar to that of the PDLLA. The PCEL and PPy/PDLLA composite therefore represent potentially important new biomaterials.

ISBN: 9780494055991Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Evaluation of biodegradable and electrically conductive polymers based on polylactide and polypyrrole.
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520 $a This thesis studied the potential of new biodegradable and electrically conductive polymers for vascular and tissue engineering applications. Newly synthesized poly(epsilon-caprolactone/poly(ethylene glycol)/L-lactide) (PCEL) and electrically conductive biodegradable polymer composite (PPy/PDLLA) were examined both in vitro and in vivo to determine their biodegradation, biocompatibility, and electrical stability. Results show that the uniform degradation of the PCEL in simple hydrolysis was as slow as that observed with PLLA. In the presence of pancreatin, the PCEL showed heterogeneous degradation. The PCEL impregnated as a sealant in vascular prostheses induced a mild inflammation in vivo in a subcutaneous model, comparable to the reactions with other clinically used biodegradable polymers. The PPy/PDLLA composite showed sufficient electrical stability to serve as a template for electrical stimulation in a biologically relevant environment. The tissue reaction of the PPy/PDLLA composite was similar to that of the PDLLA. The PCEL and PPy/PDLLA composite therefore represent potentially important new biomaterials.
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