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Adiponectin and risk factors for car...

Jessup, Ann Neighbours.

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Adiponectin and risk factors for cardiovascular disease and type 2 diabetes in Black and White youth.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Adiponectin and risk factors for cardiovascular disease and type 2 diabetes in Black and White youth./
Author:	Jessup, Ann Neighbours.
Description:	249 p.
Notes:	Adviser: Joanne S. Harrell.
Contained By:	Dissertation Abstracts International68-03B.
Subject:	Health Sciences, Epidemiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3257575

Adiponectin and risk factors for cardiovascular disease and type 2 diabetes in Black and White youth.
Jessup, Ann Neighbours.

Adiponectin and risk factors for cardiovascular disease and type 2 diabetes in Black and White youth. - 249 p.

Adviser: Joanne S. Harrell.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2007.

This study was done to examine the relationships among adiponectin and multiple risk factors for CVD and T2D in a large, racially diverse sample of youth, and to determine if relationships were moderated by gender, race and overweight status. The sample consisted of 1215 Black and White children and adolescents, aged 7-18 years, selected from 2211 subjects who participated in the Cardiovascular Health in Children III Study. Subjects who were selected had frozen serum samples available for analysis, and had complete data on the following variables: race, age, gender, pubertal stage, cardiovascular fitness, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride, insulin, glucose, systolic and diastolic blood pressure, body mass index (BMI), waist circumference, and sum of skinfolds. SAS 9.1.3 was used for all statistical analyses. Generalized Estimating Equations were used to account for the increased correlation among subjects within school clusters.Subjects--Topical Terms:

1019544
Health Sciences, Epidemiology.

Adiponectin and risk factors for cardiovascular disease and type 2 diabetes in Black and White youth.
LDR:03317nam 2200289 a 45 001 945901
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035 $a (UMI)AAI3257575
035 $a AAI3257575
040 $a UMI $c UMI
100 1 $a Jessup, Ann Neighbours. $3 1269307
245 1 0 $a Adiponectin and risk factors for cardiovascular disease and type 2 diabetes in Black and White youth.
300 $a 249 p.
500 $a Adviser: Joanne S. Harrell.
500 $a Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1558.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2007.
520 $a This study was done to examine the relationships among adiponectin and multiple risk factors for CVD and T2D in a large, racially diverse sample of youth, and to determine if relationships were moderated by gender, race and overweight status. The sample consisted of 1215 Black and White children and adolescents, aged 7-18 years, selected from 2211 subjects who participated in the Cardiovascular Health in Children III Study. Subjects who were selected had frozen serum samples available for analysis, and had complete data on the following variables: race, age, gender, pubertal stage, cardiovascular fitness, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride, insulin, glucose, systolic and diastolic blood pressure, body mass index (BMI), waist circumference, and sum of skinfolds. SAS 9.1.3 was used for all statistical analyses. Generalized Estimating Equations were used to account for the increased correlation among subjects within school clusters.
520 $a Adiponectin means were lower in Black subjects and in male subjects overall, and specifically lower in Black males than in other race/gender groups. Adiponectin means were also lower in subjects with a family history of diabetes, but there were no differences in adiponectin means by Tanner stage or fitness level. BMI z-score, waist circumference and sum of skinfolds were each inversely related to adiponectin, but BMI z-score and waist circumference provided the best models for prediction of adiponectin when compared by the Quasi-Likelihood in Independence Model Criterion (QIC). Adiponectin was positively associated with HDL-C and inversely associated with insulin and systolic blood pressure in multivariate regression with other risk factors, but the relationships with insulin and systolic blood pressure were dependent on one or more measures of adiposity. There was an interaction between HDL-C and gender, in that the relationship between adiponectin and HDL-C was stronger in female than in males. Insulin was only related to adiponectin in female subjects.
520 $a In summary, BMI z-score and waist circumference are strongly related to adiponectin. Race, gender and HDL-C are consistently related to adiponectin, independent of adiposity measures, but insulin and family history of diabetes are also important variables to consider in the study of adiponectin.
590 $a School code: 0153.
650 4 $a Health Sciences, Epidemiology. $3 1019544
650 4 $a Health Sciences, Nursing. $3 1017798
690 $a 0569
690 $a 0766
710 2 $a The University of North Carolina at Chapel Hill. $3 1017449
773 0 $t Dissertation Abstracts International $g 68-03B.
790 $a 0153
790 1 0 $a Harrell, Joanne S., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3257575