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An inconvenient truth: Leukocyte tra...

Seidman, Michael Aaron.

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An inconvenient truth: Leukocyte transendothelial migration without PECAM.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	An inconvenient truth: Leukocyte transendothelial migration without PECAM./
Author:	Seidman, Michael Aaron.
Description:	108 p.
Notes:	Adviser: William A. Muller.
Contained By:	Dissertation Abstracts International68-11B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3289651
ISBN:	9780549331353

An inconvenient truth: Leukocyte transendothelial migration without PECAM.
Seidman, Michael Aaron.

An inconvenient truth: Leukocyte transendothelial migration without PECAM. - 108 p.

Adviser: William A. Muller.

Thesis (Ph.D.)--Weill Medical College of Cornell University, 2008.

Leukocyte transendothelial migration (TEM), the process by which leukocytes leave the circulation, cross the endothelial barrier, and enter tissue to engage in effector functions, is a multistep process involving a number of different intercellular adhesion molecules. Diapedesis, the committed step of TEM, during which the leukocyte actually squeezes between endothelial cells, is known to involve at least two distinct steps, mediated by the Platelet/Endothelial Cell Adhesion Molecule (PECAM) and CD99. In the studies detailed herein, we have taken several approaches to characterizing additional molecules involved in diapedesis. Our first study uses molecular genetics in the laboratory mouse to identify a locus on mouse chromosome 2 that is apparently responsible for the ability of C57BL/6J mice to show a robust inflammatory response to thioglycollate broth even when PECAM is functionally blocked or genetically deficient. Our second study uses an in vitro model of TEM to demonstrate that prostaglandin E2 is capable of reversing the blockade in TEM seen when PECAM is inhibited. Our third study uses the same in vitro system to characterize a potentially novel step in diapedesis mediated by the molecules DNAX Accessory Molecule 1 (DNAM-1) and the Poliovirus Receptor (PVR).

ISBN: 9780549331353Subjects--Topical Terms:

1017686
Biology, Cell.

An inconvenient truth: Leukocyte transendothelial migration without PECAM.
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020 $a 9780549331353
035 $a (UMI)AAI3289651
035 $a AAI3289651
040 $a UMI $c UMI
100 1 $a Seidman, Michael Aaron. $3 1267750
245 1 3 $a An inconvenient truth: Leukocyte transendothelial migration without PECAM.
300 $a 108 p.
500 $a Adviser: William A. Muller.
500 $a Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7268.
502 $a Thesis (Ph.D.)--Weill Medical College of Cornell University, 2008.
520 $a Leukocyte transendothelial migration (TEM), the process by which leukocytes leave the circulation, cross the endothelial barrier, and enter tissue to engage in effector functions, is a multistep process involving a number of different intercellular adhesion molecules. Diapedesis, the committed step of TEM, during which the leukocyte actually squeezes between endothelial cells, is known to involve at least two distinct steps, mediated by the Platelet/Endothelial Cell Adhesion Molecule (PECAM) and CD99. In the studies detailed herein, we have taken several approaches to characterizing additional molecules involved in diapedesis. Our first study uses molecular genetics in the laboratory mouse to identify a locus on mouse chromosome 2 that is apparently responsible for the ability of C57BL/6J mice to show a robust inflammatory response to thioglycollate broth even when PECAM is functionally blocked or genetically deficient. Our second study uses an in vitro model of TEM to demonstrate that prostaglandin E2 is capable of reversing the blockade in TEM seen when PECAM is inhibited. Our third study uses the same in vitro system to characterize a potentially novel step in diapedesis mediated by the molecules DNAX Accessory Molecule 1 (DNAM-1) and the Poliovirus Receptor (PVR).
590 $a School code: 0967.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0379
690 $a 0571
690 $a 0982
710 2 $a Weill Medical College of Cornell University. $3 1021736
773 0 $t Dissertation Abstracts International $g 68-11B.
790 $a 0967
790 1 0 $a Muller, William A., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3289651