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Dietary soy protein reduces early re...

Hwang, Sun-Young.

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Dietary soy protein reduces early renal disease progression and alters prostanoid production in obese fa/fa Zucker rats.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Dietary soy protein reduces early renal disease progression and alters prostanoid production in obese fa/fa Zucker rats./
Author:	Hwang, Sun-Young.
Description:	94 p.
Notes:	Source: Masters Abstracts International, Volume: 45-03, page: 1465.
Contained By:	Masters Abstracts International45-03.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR22518
ISBN:	9780494225189

Dietary soy protein reduces early renal disease progression and alters prostanoid production in obese fa/fa Zucker rats.
Hwang, Sun-Young.

Dietary soy protein reduces early renal disease progression and alters prostanoid production in obese fa/fa Zucker rats. - 94 p.

Source: Masters Abstracts International, Volume: 45-03, page: 1465.

Thesis (M.Sc.)--University of Manitoba (Canada), 2006.

The growing epidemic of obesity in adults, as well as in children, is occurring throughout the world. It affects not only the individual's physical and mental health but carries substantial costs for the nation's economy. With the rising incidence of obesity and the metabolic syndrome, nephropathy associated with obesity also has increased. Soy protein can ameliorate disease in several models of chronic kidney disease. It also may alter the production of renal prostanoids, which may play a role in the glomerular hyperfiltration in obesity-associated nephropathy (OAN). Therefore, the effect of dietary soy protein on early disease progression and prostanoid production in OAN was examined in the obese fa/fa Zucker rat. Six-week-old male fa/fa and lean Zucker rats were offered diets ad libitum containing 17% protein from either soy protein or egg white protein for 8 weeks. Mean glomerular volume (MGV) and proteinuria were determined to assess early kidney changes and kidney function. Renal prostanoids [thromboxane B2 (TXB2), stable metabolite of TXA 2; 6-keto prostaglandin F1alpha (6-keto PGF1alpha ), stable metabolite of PGI2; and prostaglandin E2 (PGE2)] were determined by enzyme immunoassay. Renal protein and mRNA levels of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-1 (COX-1), and COX-2 were determined by western immunoblotting and QRT-PCR. Feed consumption, body and kidney weights were significantly greater in fa/fa compared to lean rats. The fa/fa rats had 43% larger MGV and 169% higher proteinuria, reflecting early development of nephropathy. Soy protein feeding did not alter body weights or proteinuria but did result in 6% lower kidney weights (g/100 g body weight) and 16% lower MGV. Prostanoid production in these kidneys was primarily due to COX-2 activity. Renal prostanoids were generally not altered by diet or genotype, however, renal 6-keto PGF1alpha levels were lower in fa/fa rats fed soy protein. Renal TXB2/PGE2 ratios were not different in rats given soy protein compared to egg white protein while renal TXB2/6-keto PGF1alpha ratios were higher and 6-keto PGF1alpha/PGE2 ratios were lower, indicating that dietary soy protein reduces renal 6-keto PGF1alpha levels. The attenuation of early nephropathy in fa/fa rats by dietary soy protein is associated with lower 6-keto PGF1alpha levels. This may affect the glomerular hyperfiltration observed in OAN.

ISBN: 9780494225189Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Dietary soy protein reduces early renal disease progression and alters prostanoid production in obese fa/fa Zucker rats.
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245 1 0 $a Dietary soy protein reduces early renal disease progression and alters prostanoid production in obese fa/fa Zucker rats.
300 $a 94 p.
500 $a Source: Masters Abstracts International, Volume: 45-03, page: 1465.
502 $a Thesis (M.Sc.)--University of Manitoba (Canada), 2006.
520 $a The growing epidemic of obesity in adults, as well as in children, is occurring throughout the world. It affects not only the individual's physical and mental health but carries substantial costs for the nation's economy. With the rising incidence of obesity and the metabolic syndrome, nephropathy associated with obesity also has increased. Soy protein can ameliorate disease in several models of chronic kidney disease. It also may alter the production of renal prostanoids, which may play a role in the glomerular hyperfiltration in obesity-associated nephropathy (OAN). Therefore, the effect of dietary soy protein on early disease progression and prostanoid production in OAN was examined in the obese fa/fa Zucker rat. Six-week-old male fa/fa and lean Zucker rats were offered diets ad libitum containing 17% protein from either soy protein or egg white protein for 8 weeks. Mean glomerular volume (MGV) and proteinuria were determined to assess early kidney changes and kidney function. Renal prostanoids [thromboxane B2 (TXB2), stable metabolite of TXA 2; 6-keto prostaglandin F1alpha (6-keto PGF1alpha ), stable metabolite of PGI2; and prostaglandin E2 (PGE2)] were determined by enzyme immunoassay. Renal protein and mRNA levels of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-1 (COX-1), and COX-2 were determined by western immunoblotting and QRT-PCR. Feed consumption, body and kidney weights were significantly greater in fa/fa compared to lean rats. The fa/fa rats had 43% larger MGV and 169% higher proteinuria, reflecting early development of nephropathy. Soy protein feeding did not alter body weights or proteinuria but did result in 6% lower kidney weights (g/100 g body weight) and 16% lower MGV. Prostanoid production in these kidneys was primarily due to COX-2 activity. Renal prostanoids were generally not altered by diet or genotype, however, renal 6-keto PGF1alpha levels were lower in fa/fa rats fed soy protein. Renal TXB2/PGE2 ratios were not different in rats given soy protein compared to egg white protein while renal TXB2/6-keto PGF1alpha ratios were higher and 6-keto PGF1alpha/PGE2 ratios were lower, indicating that dietary soy protein reduces renal 6-keto PGF1alpha levels. The attenuation of early nephropathy in fa/fa rats by dietary soy protein is associated with lower 6-keto PGF1alpha levels. This may affect the glomerular hyperfiltration observed in OAN.
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650 4 $a Health Sciences, Nutrition. $3 1017801
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710 2 0 $a University of Manitoba (Canada). $3 1018707
773 0 $t Masters Abstracts International $g 45-03.
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR22518