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In vitro penetration and retention o...

B. Rajagopalan, Bharatgopal.

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In vitro penetration and retention of sunscreen benzophenone-3 (BZ-3) across polysulfone membrane from a range of formulations.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	In vitro penetration and retention of sunscreen benzophenone-3 (BZ-3) across polysulfone membrane from a range of formulations./
Author:	B. Rajagopalan, Bharatgopal.
Description:	164 p.
Notes:	Adviser: Heather Benson.
Contained By:	Masters Abstracts International42-01.
Subject:	Health Sciences, Pharmacy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ79923
ISBN:	9780612799233

In vitro penetration and retention of sunscreen benzophenone-3 (BZ-3) across polysulfone membrane from a range of formulations.
B. Rajagopalan, Bharatgopal.

In vitro penetration and retention of sunscreen benzophenone-3 (BZ-3) across polysulfone membrane from a range of formulations. - 164 p.

Adviser: Heather Benson.

Thesis (M.Sc.)--University of Manitoba (Canada), 2002.

The penetration of sunscreen agents through a membrane was studied using polysulfone membrane (TuffrynRTM, Fischer) mounted in in vitro Franz-type vertical diffusion cells. A range of formulations was used in the study of sunscreen agents. Infinite doses were used to examine formulation effects. Solute activity (vehicle-solute interaction) was separated from membrane specific effects (solvent-skin or solute-skin interactions) by using constant thermodynamic activity. A simple and rapid high-performance liquid chromatography (HPLC) assay was validated for the quantification of sunscreen agents. A number of studies were undertaken to define appropriate receptor conditions for sunscreen absorption through membrane and sunscreen solubility. The polysulfone membrane permeation of Benzophenone-3 (Bz-3) from a range of single solvents was examined using the same Bz-3 activity in each vehicle. The maximum fluxes of Bz-3 were observed when the solubility in the vehicle was low, and when the solubility parameter of the vehicle (deltav) is different from that of the solubility parameter of the sunscreen (deltai). The flux (J) and the permeability coefficient k, were lowest when the solubility of the sunscreen in the vehicle was maximum. The flux of Bz-3 from different solvents was further increased by the presence of octyl methoxycinnamate (OM) in liquid paraffin (LP) vehicle. This work has demonstrated the importance of vehicle formulation as a determinant of sunscreen agent penetration. Maximal skin retention and minimal flux can be achieved by a combination of (1) Sunscreen lipophilicity, (2) vehicle formulation in which the sunscreen agent is most soluble, (3) a vehicle formulation such that the solubility parameter of the vehicle (deltav) is sufficiently similar to the solubility parameter of the sunscreen (deltai), and (4) the most appropriate formulation type for topical use.

ISBN: 9780612799233Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

In vitro penetration and retention of sunscreen benzophenone-3 (BZ-3) across polysulfone membrane from a range of formulations.
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100 1 $a B. Rajagopalan, Bharatgopal. $3 1265055
245 1 0 $a In vitro penetration and retention of sunscreen benzophenone-3 (BZ-3) across polysulfone membrane from a range of formulations.
300 $a 164 p.
500 $a Adviser: Heather Benson.
500 $a Source: Masters Abstracts International, Volume: 42-01, page: 0219.
502 $a Thesis (M.Sc.)--University of Manitoba (Canada), 2002.
520 $a The penetration of sunscreen agents through a membrane was studied using polysulfone membrane (TuffrynRTM, Fischer) mounted in in vitro Franz-type vertical diffusion cells. A range of formulations was used in the study of sunscreen agents. Infinite doses were used to examine formulation effects. Solute activity (vehicle-solute interaction) was separated from membrane specific effects (solvent-skin or solute-skin interactions) by using constant thermodynamic activity. A simple and rapid high-performance liquid chromatography (HPLC) assay was validated for the quantification of sunscreen agents. A number of studies were undertaken to define appropriate receptor conditions for sunscreen absorption through membrane and sunscreen solubility. The polysulfone membrane permeation of Benzophenone-3 (Bz-3) from a range of single solvents was examined using the same Bz-3 activity in each vehicle. The maximum fluxes of Bz-3 were observed when the solubility in the vehicle was low, and when the solubility parameter of the vehicle (deltav) is different from that of the solubility parameter of the sunscreen (deltai). The flux (J) and the permeability coefficient k, were lowest when the solubility of the sunscreen in the vehicle was maximum. The flux of Bz-3 from different solvents was further increased by the presence of octyl methoxycinnamate (OM) in liquid paraffin (LP) vehicle. This work has demonstrated the importance of vehicle formulation as a determinant of sunscreen agent penetration. Maximal skin retention and minimal flux can be achieved by a combination of (1) Sunscreen lipophilicity, (2) vehicle formulation in which the sunscreen agent is most soluble, (3) a vehicle formulation such that the solubility parameter of the vehicle (deltav) is sufficiently similar to the solubility parameter of the sunscreen (deltai), and (4) the most appropriate formulation type for topical use.
590 $a School code: 0303.
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