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Transdermal delivery of small and la...

Vemulapalli, Viswatej.

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Transdermal delivery of small and large molecules using iontophoresis and microneedles.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Transdermal delivery of small and large molecules using iontophoresis and microneedles./
Author:	Vemulapalli, Viswatej.
Description:	168 p.
Notes:	Adviser: Ajay K. Banga.
Contained By:	Dissertation Abstracts International69-02B.
Subject:	Health Sciences, Pharmacy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3303124
ISBN:	9780549491811

Transdermal delivery of small and large molecules using iontophoresis and microneedles.
Vemulapalli, Viswatej.

Transdermal delivery of small and large molecules using iontophoresis and microneedles. - 168 p.

Adviser: Ajay K. Banga.

Thesis (Ph.D.)--Mercer University, 2008.

In summary, iontophoresis in combination with microneedles has significantly enhanced the transdermal delivery of both small and large molecules.

ISBN: 9780549491811Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Transdermal delivery of small and large molecules using iontophoresis and microneedles.
LDR:03343nam 2200337 a 45 001 940885
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008 110518s2008 ||||||||||||||||| ||eng d
020 $a 9780549491811
035 $a (UMI)AAI3303124
035 $a AAI3303124
040 $a UMI $c UMI
100 1 $a Vemulapalli, Viswatej. $3 1265015
245 1 0 $a Transdermal delivery of small and large molecules using iontophoresis and microneedles.
300 $a 168 p.
500 $a Adviser: Ajay K. Banga.
500 $a Source: Dissertation Abstracts International, Volume: 69-02, Section: B, page: 0966.
502 $a Thesis (Ph.D.)--Mercer University, 2008.
520 $a In summary, iontophoresis in combination with microneedles has significantly enhanced the transdermal delivery of both small and large molecules.
520 $a Methotrexate showed no evidence of lateral diffusion over 8 hrs. The combination of iontophoresis and microneedles significantly enhanced the transdermal delivery of salmon calcitonin when compared to that iontophoresis and microneedles alone.
520 $a Skin is normally permeable only to lipophilic drugs but various enhancement techniques can enable delivery of hydrophilic drugs. The aims of this work were to evaluate enhancement techniques like iontophoresis, microneedles and their combination on delivering weakly basic (SLV 318), weakly acidic (methotrexate) and a peptide (salmon calcitonin) drug molecule. In addition, lateral diffusion of methotrexate in hairless rat skin was studied using in vitro microdialysis model.
520 $a Effect of counter-ions and temperature were investigated on the solubility of SLV 318. Anodal iontophoresis was used to deliver SLV 318 in vitro and in vivo in hairless rats. Pharmacokinetic parameters were determined to calculate the total dose delivered.
520 $a Iontophoretic parameters like buffer strength or drug concentration were evaluated. A response surface model evaluated current density and time of application. Then, iontophoresis with optimum formulation parameters was further combined with microneedles for delivery of methotrexate in vitro and in vivo.
520 $a Lateral diffusion of methotrexate was studied using in vitro microdialysis. Cathodal iontophoresis was used to deliver methotrexate and samples were collected from microdialysis and as well as the receptor. After the study, tape stripping was done to measure the drug levels in the skin. In vivo delivery of salmon calcitonin was studied using iontophoresis, microneedles and their combination using soluble maltose or metal microneedles.
520 $a SLV 318 had higher solubility with NaCl as a counter-ion at 25°C when compared to that with other counter-ions. Iontophoresis significantly enhanced the in vitro and in vivo delivery of SLV 318. Response surface model using factorial design shows an increase in cumulative amount of methotrexate delivered with an increase in current density and time of application. The optimized iontophoretic parameters, when used in combination with maltose microneedles significantly, enhanced the delivery of methotrexate.
590 $a School code: 1160.
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0572
710 2 $a Mercer University. $3 1265016
773 0 $t Dissertation Abstracts International $g 69-02B.
790 $a 1160
790 1 0 $a Banga, Ajay K., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3303124